D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt

Name: D- myo -Inositol-1,3,4,5- tetrakis phosphate, octapotassium salt
Brand: Tocris Bioscience
SKU: 1420

Cat. No. 1420 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1420 has been discontinued.

View all Inositol Phosphatases products.

说明： Potent inhibitor of Ins(1,4,5)P₃ 5-phosphatase. Metabolite of Cat. No. 1482

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性

D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt is a phosphorylation product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P₃). Potent inhibitor of Ins (1,4,5)P₃ 5-phosphatase (IC₅₀ ~150 nM); facilitates Ca²⁺ influx by sensitizing Ins (1,4,5)P₃-mediated activation of I_CRAC. At higher concentrations, acts as an inhibitor of Ins (1,4,5)P₃ receptors.

技术数据

分子量	804.73
公式	C₆H₈O₁₈P₄.K₈
储存	Desiccate at -20°C
纯度	≥98% (HPLC)
CAS Number	145843-69-2
PubChem ID	16760517
InChI Key	HDLWTQSZUMYYND-QAVKKEKOSA-F
Smiles	[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].O[C@H]1[C@@H](OP([O-])([O-])=O)[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H]1OP([O-])([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书

分析证书/产品说明书

化学品安全技术说明书

参考文献

参考文献是支持产品生物活性的出版物。

Balla et al (1991) Agonist-induced calcium signaling is impaired in fibroblasts overproducing inositol 1,3,4,5-tetrakisphosphate. J.Biol.Chem. 266 24719 PMID: 1662215

Cullen et al (1998) Bridging the GAP in inositol 1,3,4,5-tetrakisphosphate signalling. Biochim.Biophys.Acta 1436 35 PMID: 9838034

Hermosura et al (2000) InsP₄ facilitates store-operated calcium influx by inhibition of InsP₃ 5-phosphatase. Nature 408 735 PMID: 11130077

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关键词: D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt, D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt supplier, Potent, inhibitors, inhibits, Ins145P3, 5-phosphatase, Inositol, Lipids, Phosphatases, 1420, Tocris Bioscience

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