Inositol Lipids
Inositol lipids are the structural basis of many second messenger molecules in eukaryotic cells, such as inositol monophosphate, inositol triphosphate (IP3) and inositol 1,4,5-trisphosphate (Ins (1,4,5)P3). Inositol lipid signaling pathways are regulated by phosphorylation.
Inositol Lipid Antagonists |
|
|---|---|
| Cat. No. | 产品名称/活性 |
| 1224 | 2-APB |
| IP3 receptor antagonist; also TRP channel modulator | |
Inositol Lipid Inhibitors |
|
| Cat. No. | 产品名称/活性 |
| 4839 | AZD 6482 |
| Potent and selective PI 3-Kβ inhibitor | |
| 3606 | BAG 956 |
| Dual PI 3-kinase and PDPK1 (PDK1) inhibitor | |
| 0681 | L-690,330 |
| Inositol monophosphatase inhibitor | |
| 1130 | LY 294002 hydrochloride |
| Prototypical PI 3-kinase inhibitor; also inhibits other kinases | |
| 3977 | 3-Methyladenine |
| Class III PI 3-kinase inhibitor; also inhibits autophagy | |
| 2930 | PI 103 hydrochloride |
| Inhibitor of PI 3-kinase, mTOR and DNA-PK | |
| 2814 | PI 828 |
| PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130) | |
| 1125 | Quercetin |
| Non-selective PI 3-kinase inhibitor | |
| 3946 | TNP |
| Inhibitor of IP6K; also inhibits IP3K | |
| 1232 | Wortmannin |
| Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 | |
Inositol Lipid Activators |
|
| Cat. No. | 产品名称/活性 |
| 1983 | 740 Y-P |
| Cell-permeable PI 3-kinase activator | |
Other |
|
| Cat. No. | 产品名称/活性 |
| 1482 | D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt |
| Ca2+ mobilizing second messenger | |
Inositol lipids are the structural basis of many second messenger molecules in eukaryotic cells, such as inositol monophosphate, inositol triphosphate (IP3) and inositol 1,4,5-trisphosphate (Ins (1,4,5)P3).
In response to GPCR and receptor tyrosine kinase activation, PI 3-kinase phosphorylates some inositol lipids, such as PI(3,4,5)P3, and PLC mediates inositol lipid cleavage to generate further second messengers such as DAG and IP3. IP3 subsequently acts upon IP3 receptors located in the ER membrane and mediates Ca2+ release.
Regulation of inositol lipid signaling pathways is through phosphorylation (e.g. by inositol-tetrakisphosphate 1-kinase) and dephosphorylation (e.g. by inositol monophosphatase (IMPase)) of inositol lipids. This large group of proteins constitute a major intracellular signal transduction network. Because of this, inositol lipids are involved in a vast number of physiological processes.
Inositol Lipid Signaling Pathway Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| IMPase 1 | Human | IMPA1 | NM_005536 | P29218 |
| Mouse | Impa1 | NM_018864 | O55023 | |
| Rat | Impa1 | NM_032057 | P97618 | |
| IMPase 2 | Human | IMPA2 | NM_014214 | O14732 |
| Mouse | Impa2 | NM_053261 | Q91UZ5 | |
| Rat | Impa2 | NM_172224 | Q8CIN7 | |
| Inositol Polyphosphate-1-Phosphatase | Human | INPP1 | NM_001128928 | P49441 |
| Mouse | Inpp1 | NM_008384 | P49442 | |
| Rat | Inpp1 | NM_001012131 | Q5RJK6 | |
| Inositol Hexakisphosphate Kinase 1 | Human | IP6K1 | NM_153273 | Q92551 |
| Mouse | Ip6k1 | NM_013785 | Q6PD10 | |
| Rat | Ip6k1 | NM_053316 | Q9ESM0 | |
| Inositol Polyphosphate Multikinase | Human | IPMK | NM_152230 | Q8NFU5 |
| Mouse | Ipmk | NM_027184 | Q7TT16 | |
| Rat | Ipmk | NM_134417 | Q99NI4 | |
| PI 3-K | ||||
|
Class IA p85α, p50α, p55α |
Human | PIK3R1 | NM_181504 | P27986 |
| Mouse | Pik3r1 | NM_001077495 | P26450 | |
| Rat | Pik3r1 | NM_013005 | O55168 | |
|
Class IA p85β |
Human | PIK3R2 | NM_005027 | O00459 |
| Mouse | Pik3r2 | NM_008841 | O08908 | |
| Rat | Pik3r2 | NM_022185 | Q63788 | |
|
Class IA p55γ |
Human | PIK3R3 | NM_003629 | Q92569 |
| Mouse | Pik3r3 | NM_181585 | Q64143 | |
| Rat | Pik3r3 | NM_022213 | Q63789 | |
|
Class IA p110α |
Human | PIK3CA | NM_006218 | P42336 |
| Mouse | Pik3ca | NM_008839 | P42337 | |
| Rat | Pik3ca | BC099154 | Q4KLK3 | |
|
Class IA p110β |
Human | PIK3CB | NM_006219 | P42338 |
| Mouse | Pik3cb | NM_029094 | Q8BTI9 | |
| Rat | Pik3cb | NM_053481 | Q9Z1L0 | |
|
Class IA p110δ |
Human | PIK3CD | NM_005026 | O00329 |
| Mouse | Pik3cd | NM_008840 | O35904 | |
|
Class IB p101 |
Human | PIK3R5 | NM_014308 | Q8WYR1 |
| Mouse | Pik3r5 | NM_177320 | Q5SW28 | |
|
Class IB p101γ |
Human | PIK3CG | NM_002649 | P48736 |
| Mouse | Pik3cg | NM_020272 | Q9JHG7 | |
|
Class II C2α |
Human | PIK3C2A | NM_002645 | O00443 |
| Mouse | Pik3c2a | NM_011083 | Q61194 | |
|
Class II C2β |
Human | PIK3C2B | NM_002646 | O00750 |
| Mouse | Pik3c2b | AK049181 | A2RSK1 | |
|
Class II C2γ |
Human | PIK3C2G | NM_004570 | O75747 |
| Mouse | Pik3c2g | NM_207683 | O70167 | |
| Rat | Pik3c2g | NM_053923 | O70173 | |
|
Class III p150 |
Human | PIK3R4 | NM_014602 | Q99570 |
| Mouse | Pik3r4 | NM_001081309 | Q8VD65 | |
|
Class III Vps34 |
Human | PIK3C3 | NM_002647 | Q8NEB9 |
| Mouse | Pik3c3 | NM_181414 | Q6PF93 | |
| Rat | Pik3c3 | NM_022958 | O88763 | |
| PLC | ||||
| PLCβ1 | Human | PLCB1 | NM_015192 | Q9NQ65 |
| Mouse | Plcb1 | NM_019677 | Q9Z1B3 | |
| Rat | Plcb1 | NM_001077641 | P10687 | |
| PLCβ2 | Human | PLCB1 | NM_004573 | Q00722 |
| Mouse | Plcb2 | NM_177568 | A3KGF7 | |
| Rat | Plcb2 | NM_053478 | O89040 | |
| PLCβ3 | Human | PLCB3 | NM_000932 | Q01970 |
| Mouse | Plcb3 | NM_008874 | P51432 | |
| Rat | Plcb3 | NM_033350 | Q45QJ4 | |
| PLCβ4 | Human | PLCB4 | NM_000933 | Q9UJQ2 |
| Mouse | Plcb4 | NM_013829 | NP_038857 | |
| Rat | Plcb4 | NM_024353 | Q9QW07 | |
| PLCγ1 | Human | PLCG1 | NM_182811 | P19174 |
| Mouse | Plcg1 | NM_021280 | Q62077 | |
| Rat | Plcg1 | NM_013187 | P10686 | |
| PLCγ2 | Human | PLCG2 | NM_002661 | P16885 |
| Mouse | Plcg2 | NM_172285 | Q8CIH5 | |
| Rat | Plcg2 | NM_017168 | P24135 | |
| PLCδ1 | Human | PLCD1 | NM_006225 | P51178 |
| Mouse | Plcd1 | NM_019676 | Q8R3B1 | |
| Rat | Plcd1 | NM_017035 | P10688 | |
| PLCδ3 | Human | PLCD3 | NM_133373 | Q8N3E9 |
| Mouse | Plcd3 | NM_152813 | Q8K2J0 | |
| Rat | Plcd3 | NM_001105845 | XP_221004 | |
| PLCδ4 | Human | PLCD4 | NM_032726 | Q9BRC7 |
| Mouse | Plcd4 | NM_148937 | Q8K3R3 | |
| Rat | Plcd4 | NM_080688 | Q62711 | |
| PLCε1 | Human | PLCE1 | NM_016341 | Q9P212 |
| Mouse | Plce1 | NM_019588 | Q8K4S1 | |
| Rat | Plce1 | NM_053758 | Q99P84 | |
| PLCζ1 | Human | PLCZ1 | NM_033123 | Q86YW0 |
| Mouse | Plcz1 | NM_054066 | Q8K4D7 | |
| Rat | Plcz1 | NM_001012234 | Q5FX52 | |
| PLCη1 | Human | PLCH1 | NM_014996 | Q4KWH8 |
| Mouse | Plch1 | NM_183191 | Q4KWH5 | |
| Rat | Plch1 | XM_227208 | XP_227208 | |
| PLCη2 | Human | PLCH2 | NM_014638 | O75038 |
| Mouse | Plch2 | NM_175556 | A2AP18 | |
| Rat | Plch2 | XM_233728 | XP_233728 | |
| IP3 | ||||
| IP3R1 | Human | ITPR1 | NM_002222 | Q14643 |
| Mouse | Itpr1 | NM_010585 | P11881 | |
| Rat | Itpr1 | NM_001007235 | Q5BJS8 | |
| IP3R2 | Human | ITPR2 | NM_002223 | Q14571 |
| Mouse | Itpr2 | NM_019923 | Q9Z329 | |
| Rat | Itpr2 | NM_031046 | Q6W3E4 | |
| IP3R3 | Human | ITPR3 | NM_002224 | Q14573 |
| Mouse | Itpr3 | NM_080553 | P70227 | |
| Rat | Itpr3 | NM_013138 | Q63269 | |