[D-p-Cl-Phe⁶,Leu¹⁷]-VIP

Cat. No. 3054 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective VIP receptor antagonist

纯度： ≥95% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

[D-p-Cl-Phe⁶,Leu¹⁷]-VIP is a selective vasoactive intestinal peptide (VIP) receptor antagonist (IC₅₀ = 125.8 nM). Displays no activity on glucagon, secretin or GRF receptors.

技术数据 for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

分子量	3342.24
公式	C₁₄₈H₂₃₉ClN₄₄O₄₂
序列	HSDAVFTDNYTRLRKQLAVKKYLNSILN (Modifications: Phe-6 = p-Cl-D-Phe, Asn-34 = C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	102805-45-8
PubChem ID	90488798
InChI Key	BUTRVBZATBJGPP-BERWWWERSA-N
Smiles	[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC1=CC=C(Cl)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

溶解性	Soluble to 1 mg/ml in water

产品说明书 for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

分析证书/产品说明书

化学品安全技术说明书

参考文献 for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP

参考文献是支持产品生物活性的出版物。

Pandol et al (1986) Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe⁶,Leu¹⁷]VIP. Am.J.Physiol. 250 G553 PMID: 2421587

Pozo et al (1997) Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur.J.Pharmacol. 321 379 PMID: 9085051

Xie et al (2007) Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells. Mol.Pharmacol. 72 73 PMID: 17430995

If you know of a relevant reference for [D-p-Cl-Phe⁶,Leu¹⁷]-VIP, please let us know.

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关键词: [D-p-Cl-Phe6,Leu17]-VIP, [D-p-Cl-Phe6,Leu17]-VIP supplier, Selective, VIP, receptor, antagonists, Vasoactive, Intestinal, Peptide, Receptors, VPAC, 3054, Tocris Bioscience

4 篇 [D-p-Cl-Phe⁶,Leu¹⁷]-VIP 的引用文献

引用文献是使用了 Tocris 产品的出版物。 [D-p-Cl-Phe⁶,Leu¹⁷]-VIP 的部分引用包括：

Nedvetsky et al (2014) Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell 30 449 PMID: 25158854

Maugeri et al (2016) PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Sci Rep 7 139 PMID: 27303300

Jones et al (2015) Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior. Nat Neurosci 18 373 PMID: 25643294

Evans et al (2013) Dynamic interactions mediated by nonredundant signaling mechanisms couple circadian clock neurons. Neuron 80 973 PMID: 24267653

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