[D-Phe¹²,Leu¹⁴]-Bombesin

Name: [D-Phe 12 ,Leu 14 ]-Bombesin
Brand: Tocris Bioscience
SKU: 3422

Cat. No. 3422 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3422 has been discontinued.

View all Bombesin Receptors products.

说明： Bombesin receptor antagonist

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for [D-Phe¹²,Leu¹⁴]-Bombesin

[D-Phe¹²,Leu¹⁴]-Bombesin is a bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC₅₀ value of 2 μM. Inhibits amylase release in vitro (IC₅₀ = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.

技术数据 for [D-Phe¹²,Leu¹⁴]-Bombesin

分子量	1610.9
公式	C₇₅H₁₁₄N₂₂O₁₈
序列	XQRLGNQWAVGFLL (Modifications: X = Glp, Phe-12 = D-Phe, Leu-14 = C-terminal amide)
储存	Store at -20°C
CAS Number	108437-88-3
PubChem ID	16168803
InChI Key	PWGHKRYOBBMXGB-TVXZQRGPSA-N
Smiles	[H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for [D-Phe¹²,Leu¹⁴]-Bombesin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for [D-Phe¹²,Leu¹⁴]-Bombesin

参考文献是支持产品生物活性的出版物。

Heinz-Erian et al (1987) [d-Phe¹²]bombesin analogues: a new class of bombesin receptor antagonists. Am.J.Physiol. 252 G439 PMID: 2435173

Merali et al (1988) (d-Phe12) bombesin and substance P analogues function as central bombesin receptor antagonists. Synapse 2 282 PMID: 2463692

Flynn (1997) Bombesin receptor antagonists block the effects of exogenous bombesin but not of nutrients on food intake. Physiol.Behav. 62 791 PMID: 9284499

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关键词: [D-Phe12,Leu14]-Bombesin, [D-Phe12,Leu14]-Bombesin supplier, Bombesin, receptor, antagonists, GRP-Preferring, Receptors, BB1, BB2, BB3, Gastrin-Releasing, Peptide-Preferring, NMB-Preferring, Neuromedin, B-Preferring, 3422, Tocris Bioscience

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