[D-Trp³⁴]-Neuropeptide Y

Name: [D-Trp 34 ]-Neuropeptide Y
Brand: Tocris Bioscience
SKU: 3436

Cat. No. 3436 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3436 has been discontinued.

View all NPY Receptors products.

说明： Potent NPY Y₅ agonist; orexigenic

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for [D-Trp³⁴]-Neuropeptide Y

[D-Trp³⁴]-Neuropeptide Y is a potent neuropeptide Y (NPY) Y₅ receptor agonist (pEC₅₀ values are 7.82, 6.28, 6.44 and > 6 at rat Y₅, Y₄, Y₁ and Y₂ receptors respectively) that displays > 26-fold, > 1000-fold and > 1000-fold selectivity over Y₁, Y₂ and Y₄ receptors respectively. Induces hyperphagia, body weight gain, adiposity, hypercholesterolemia, hyperinsulinemia and hyperleptinemia in vivo. Orally active.

技术数据 for [D-Trp³⁴]-Neuropeptide Y

分子量	4311.77
公式	C₁₉₆H₂₈₉N₅₅O₅₆
序列	YPSKPDNPGEDAPAEDLARYYSALRHYINLITRWRY (Modifications: Trp-34 = D-Trp, Tyr-36 = C-terminal amide)
储存	Store at -20°C
CAS Number	153549-84-9
PubChem ID	16132265
InChI Key	IDLFZVILOHSSID-OVLDLUHVSA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for [D-Trp³⁴]-Neuropeptide Y

分析证书/产品说明书

化学品安全技术说明书

参考文献 for [D-Trp³⁴]-Neuropeptide Y

参考文献是支持产品生物活性的出版物。

Parker et al (2000) [D-Trp³⁴] neuropeptide Y is a potent and selective neuropeptide Y Y5 receptor agonist with dramatic effects on food intake. Peptides 21 393 PMID: 10793222

Mashiko et al (2003) Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp³⁴NPY. Endocrinology 144 1793 PMID: 12697685

Beck et al (2007) Responsiveness of obese Zucker rats to [D-Trp³⁴]-NPY supports the targeting of Y5 receptor for obesity treatment. Nutr.Neurosci. 10 211 PMID: 18284029

按标靶查看相关产品

按产品操作查看相关产品

查看全部 NPY Receptor Agonists

关键词: [D-Trp34]-Neuropeptide Y, [D-Trp34]-Neuropeptide Y supplier, Potent, NPY, Y5, agonists, orexigenic, Neuropeptide, Y, Receptors, [D-Trp34]-NeuropeptideY, neuropeptides, 3436, Tocris Bioscience

篇 [D-Trp³⁴]-Neuropeptide Y 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 [D-Trp³⁴]-Neuropeptide Y 的引用文献。