主页 / 药理学 / GPCRs / 7-TM Receptors / Free Fatty Acid Receptors / Free Fatty Acid Receptor Antagonists / DC 260126

DC 260126

Cat. No. 5357 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： FFA1 (GPR40) antagonist
化学名： N-(4-Butylphenyl)-4-fluorobenzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DC 260126

DC 260126 is a free fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca2+ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic (db/db) rats.

化合物库 for DC 260126

DC 260126 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for DC 260126

分子量 307.38
公式 C16H18FNO2S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 346692-04-4
PubChem ID 2843133
InChI Key CNGHPXKWPGIDSK-UHFFFAOYSA-N
Smiles CCCCC(C=C2)=CC=C2NS(C1=CC=C(F)C=C1)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DC 260126

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.74 100
ethanol 30.74 100

制备储备液 for DC 260126

以下数据基于产品分子量 307.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.53 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for DC 260126

参考文献是支持产品生物活性的出版物。

Zhang et al (2010) DC260126, a small-molecule antagonist of GPR40, improves Ins tolerance but not glucose tolerance in obese Zucker rats. Biomed.Pharmacother. 64 647 PMID: 20888730

Sun et al (2013) DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS ONE 8 e66744 PMID: 23776696

Hu et al (2009) A novel class of antagonists for the FFAs receptor GPR40. Biochem.Biophys.Res.Comm. 390 557 PMID: 19818732

If you know of a relevant reference for DC 260126, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Free Fatty Acid Receptor Antagonists

关键词: DC 260126, DC 260126 supplier, DC260126, GPR40, free, fatty, acid, receptors, 1, FFA1, insulin, sensitivity, Free, Fatty, Acid, Receptors, 5357, Tocris Bioscience

篇 DC 260126 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 DC 260126 的引用文献。 您是否知道使用了 Tocris DC 260126 的优秀论文？ 请告知我们.

DC 260126 的评论

目前没有该产品的评论。 Be the first to review DC 260126 and earn rewards!

Have you used DC 260126?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review