DDR1-IN-1 dihydrochloride

Name: DDR1-IN-1 dihydrochloride
Brand: Tocris Bioscience
SKU: 5077
Rating: 5 (1 reviews)

Cat. No. 5077 6 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective DDR1 inhibitor

化学名： N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for DDR1-IN-1 dihydrochloride

DDR1-IN-1 dihydrochloride is a selective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC₅₀ values are 105 and 413 nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.

External Portal Information for DDR1-IN-1 dihydrochloride

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of DDR1-IN-1 is reviewed on the chemical probes website.

化合物库 for DDR1-IN-1 dihydrochloride

DDR1-IN-1 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for DDR1-IN-1 dihydrochloride

分子量	625.51
公式	C₃₀H₃₁F₃N₄O₃.2HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1780303-76-5
PubChem ID	90489006
InChI Key	PBUOJKYQZINPKD-UHFFFAOYSA-N
Smiles	CC1=C(OC4=CC(CC(N5)=O)=C5C=C4)C=C(NC(C2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)C=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DDR1-IN-1 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	62.55	100
	DMSO	31.28	50

制备储备液 for DDR1-IN-1 dihydrochloride

以下数据基于产品分子量 625.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.6 mL	7.99 mL	15.99 mL
5 mM	0.32 mL	1.6 mL	3.2 mL
10 mM	0.16 mL	0.8 mL	1.6 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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产品说明书 for DDR1-IN-1 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for DDR1-IN-1 dihydrochloride

参考文献是支持产品生物活性的出版物。

Kim et al (2013) Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS.Chem.Biol. 8 2145 PMID: 23899692

Canning et al (2014) Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors. J.Mol.Biol. 426 2457 PMID: 24768818

If you know of a relevant reference for DDR1-IN-1 dihydrochloride, please let us know.

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关键词: DDR1-IN-1 dihydrochloride, DDR1-IN-1 dihydrochloride supplier, selective, discoidin, domain, receptors, DDR1, DDR2, tyrosine, kinases, Other, RTKs, 5077, Tocris Bioscience