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Submit ReviewDelavirdine mesylate
说明： Non-nucleoside reverse transcriptase inhibitor
别名： U 90152
化学名： 1-[3-[(1-Methylethyl)amino]-2-pyridinyl]-4-[[5-[(methylsulfonyl)amino]-1H-indol-2-yl]carbonyl]-piperazine monomethanesulfonate
纯度： ≥99% (HPLC)
生物活性 for Delavirdine mesylate
Delavirdine mesylate is a non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC50 values are 0.26, 440 and >550 μM for HIV-1 reverse transcriptase, DNA polymerase α and DNA polymerase δ). Prevents HIV-1 spread in vivo and blocks viral replication in peripheral blood lymphocytes. Orally active.
许可信息
Sold for research purposes under agreement from Viiv.
化合物库 for Delavirdine mesylate
Delavirdine mesylate is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Delavirdine mesylate
| 分子量 | 552.67 |
| 公式 | C22H28N6O3S.CH3SO3H |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 147221-93-0 |
| PubChem ID | 441386 |
| InChI Key | MEPNHSOMXMALDZ-UHFFFAOYSA-N |
| Smiles | O=C(N3CCN(C4=NC=CC=C4NC(C)C)CC3)C2=CC1=CC(NS(=O)(C)=O)=CC=C1N2.CS(O)(=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Delavirdine mesylate
参考文献 for Delavirdine mesylate
参考文献是支持产品生物活性的出版物。
Dueweke et al (1993) U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob.Agents Chemother. 37 1127 PMID: 7685995
Pagano and Chong (1995) In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavi. (U-90152) with protease inhibitor U-75875 or IF.-alpha. J.Infect.Dis. 171 61 PMID: 7528253
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关键词: Delavirdine mesylate, Delavirdine mesylate supplier, reverse, transcriptase, inhibitors, inhibits, polymerases, RNA/DNA, antivirals, antiretrovirals, HIV, non-nucleoside, NNRTI, HIV-1, U90152, U, 90152, DNA, Polymerase, 4149, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.