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Submit ReviewDexmedetomidine hydrochloride
说明： Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)
别名： d-Medetomidine hydrochloride
化学名： 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
纯度： ≥98%
生物活性 for Dexmedetomidine hydrochloride
Dexmedetomidine hydrochloride is an active isomer of medetomidine, a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than Clonidine (Cat. No. 0690) and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.
Racemate also available.
化合物库 for Dexmedetomidine hydrochloride
Dexmedetomidine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Dexmedetomidine hydrochloride
| 分子量 | 236.74 |
| 公式 | C13H16N2.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% |
| CAS Number | 145108-58-3 |
| PubChem ID | 6918081 |
| InChI Key | VPNGEIHDPSLNMU-MERQFXBCSA-N |
| Smiles | C[C@H](C2=CN=CN2)C1=C(C)C(C)=CC=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Dexmedetomidine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 23.67 | 100 | |
| DMSO | 23.67 | 100 |
制备储备液 for Dexmedetomidine hydrochloride
以下数据基于产品分子量 236.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.22 mL | 21.12 mL | 42.24 mL |
| 5 mM | 0.84 mL | 4.22 mL | 8.45 mL |
| 10 mM | 0.42 mL | 2.11 mL | 4.22 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
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产品说明书 for Dexmedetomidine hydrochloride
参考文献 for Dexmedetomidine hydrochloride
参考文献是支持产品生物活性的出版物。
Virtanen et al (1988) Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist. Eur.J.Pharmacol. 150 9 PMID: 2900154
Fisher et al (1991) Antinociceptive properties of intrathecal dexmedetom. in rats. Eur.J.Pharmacol. 192 221 PMID: 1674472
Scheinin et al (1989) Medetomidine - a novel α2-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 13 635 PMID: 2571177
If you know of a relevant reference for Dexmedetomidine hydrochloride, please let us know.
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关键词: Dexmedetomidine hydrochloride, Dexmedetomidine hydrochloride supplier, Active, isomer, α2-Adrenergic, alpha2-Adrenergic, Receptors, α2-adrenoceptor, alpha2-adrenoceptors, a2-adrenoceptors, a2-adrenergic, d-Medetomidine, hydrochloride, Adrenergic, Alpha-2, 2749, Tocris Bioscience
7 篇 Dexmedetomidine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Dexmedetomidine hydrochloride 的部分引用包括：
Ma et al (2019) Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation Curr Biol 29 3315 PMID: 31543455
Garrity et al (2015) Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat. Invest Ophthalmol Vis Sci 38 73 PMID: 25325438
McAlvin et al (2015) Corneal Anesthesia With Site 1 Sodium Channel Blockers and dexmedetom. J Inflamm (Lond) 56 3820 PMID: 26066750
Yuki et al (2011) Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. Anesth Analg 112 830 PMID: 21385989
Uchida et al (2019) Induction of Non-Apoptotic Cell Death by Adrenergic Agonists in Human Oral Squamous Cell Carcinoma Cell Lines. Anticancer Res 39 3519 PMID: 31262876
Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788
Gozzi et al (2013) Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine. Neuropsychopharmacology 38 2120 PMID: 23736277
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.