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Submit ReviewDiazoxide
说明： Inhibits AMPA desensitization
化学名： 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
纯度： ≥98% (HPLC)
生物活性 for Diazoxide
Diazoxide is an antihypertensive, activates ATP-dependent K+ channels (Kir6). Induces activation of PKCε, an intermediate in the opening of mitoKATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.
化合物库 for Diazoxide
Diazoxide is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Diazoxide
| 分子量 | 230.67 |
| 公式 | C8H7ClN2O2S |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 364-98-7 |
| PubChem ID | 3019 |
| InChI Key | GDLBFKVLRPITMI-UHFFFAOYSA-N |
| Smiles | CC1=NC2=C(C=C(Cl)C=C2)S(=O)(=O)N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Diazoxide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 23.07 | 100 |
制备储备液 for Diazoxide
以下数据基于产品分子量 230.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.34 mL | 21.68 mL | 43.35 mL |
| 5 mM | 0.87 mL | 4.34 mL | 8.67 mL |
| 10 mM | 0.43 mL | 2.17 mL | 4.34 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.87 mL |
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产品说明书 for Diazoxide
参考文献 for Diazoxide
参考文献是支持产品生物活性的出版物。
Kim et al (2006) Dox acts more as a PKC-ε activator, and indirectly activates the mitochondiral KATP channel conferring cardioprotection against hypoxic injury. Br.J.Pharmacol. 149 1059 PMID: 17043673
Trube et al (1986) Opposite effects of tolbut. and Dox on the ATP-dependent K+ channel in mouse pancreatic β-cells. Pflugers Arch. 407 493 PMID: 2431383
Yamada and Rothman (1992) Dox blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons. J.Physiol. 458 409 PMID: 1302270
Merck Index 12 3051
If you know of a relevant reference for Diazoxide, please let us know.
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关键词: Diazoxide, Diazoxide supplier, Blocks, desensitization, desensitisation, AMPA, receptors, K+, channel, opener, KATP, Glutamate, Receptors, iGlur, Ionotropic, Potassium, KIR, Kir6, Channels, Inward, Rectifier, rectifier, 0964, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Diazoxide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
4 篇 Diazoxide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Diazoxide 的部分引用包括：
Cox et al (2014) Chronic neonatal Dox therapy is not associated with adverse effects J Neurosci 14 49 PMID: 25587244
Niu et al (2011) Sex differences in the contribution of ATP-sensitive K+ channels in trigeminal ganglia under an acute muscle pain condition. Neuroscience 180 344 PMID: 21296645
Frazão et al (2013) Shift in Kiss1 cell activity requires estrogen receptor α. J Neurosci 33 2807 PMID: 23407940
Sun et al (2014) Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci Rep 4 4934 PMID: 24816792
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