Dihydroergotamine mesylate

Cat. No. 0475 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： α partial agonist; also D₂-like partial agonist and 5-HT antagonist

化学名： 9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione mesylate

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Dihydroergotamine mesylate

Dihydroergotamine mesylate is a partial α-adrenergic agonist. Partial D₂ dopaminergic receptor agonist. Competitive 5-HT antagonist.

化合物库 for Dihydroergotamine mesylate

Dihydroergotamine mesylate is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Dihydroergotamine mesylate

分子量	679.79
公式	C₃₃H₃₇N₅O₅.CH₃SO₃H
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	6190-39-2
PubChem ID	71171
InChI Key	ADYPXRFPBQGGAH-UMYZUSPBSA-N
Smiles	CS(=O)(O)=O.[H][C@]4([C@@]([H])3C[C@@H]([C@@](N[C@@]5(C)C(N([C@@]([H])(CC8=CC=CC=C8)C(N7[C@]([H])6CCC7)=O)[C@@]6(O)O5)=O)=O)CN4C)CC1=CNC2=C1C3=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Dihydroergotamine mesylate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	67.97	100

制备储备液 for Dihydroergotamine mesylate

以下数据基于产品分子量 679.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.47 mL	7.36 mL	14.71 mL
5 mM	0.29 mL	1.47 mL	2.94 mL
10 mM	0.15 mL	0.74 mL	1.47 mL
50 mM	0.03 mL	0.15 mL	0.29 mL

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产品说明书 for Dihydroergotamine mesylate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Dihydroergotamine mesylate

参考文献是支持产品生物活性的出版物。

de Boer et al (1991) Carotid vascular effects of ergot. and dihydroergot. in the pig: no exclusive mediation via 5-HT₁-like receptors. Br.J.Pharmacol. 104 183 PMID: 1664762

Doggrell et al (1992) Further analysis of the inhibitory effects of dihydroergotamine, cyprohept. and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine. J.Auton.Pharmacol. 12 223 PMID: 1512277

Lesage et al (1998) Agonistic properties of alniditan, sumatr. and dihydroergot. on human 5-HT_1B and 5-HT_1D receptors expressed in various mammalian cell lines. Br.J.Pharmacol. 123 1655 PMID: 9605573

Villalon et al (1992) Effects of S9977 and dihydroergot. in an animal experimental model for migraine. Pharmacol.Res. 25 125 PMID: 1635891

If you know of a relevant reference for Dihydroergotamine mesylate, please let us know.

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关键词: Dihydroergotamine mesylate, Dihydroergotamine mesylate supplier, 5-HT, antagonists, partial, agonists, a-adrenergic, α-adrenergic, alpha-adrenergic, dopaminergic, D2, receptors, Partial, D2-like, alpha, Non-Selective, Serotonin, 5-HT3, Receptors, 5-Hydroxytryptamine, Dopamine, α-adrenoceptors, α-adrenoceptor, alpha-adrenocep, Non-selective, Adrenergic, Alpha, 0475, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Dihydroergotamine mesylate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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