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DIM

Cat. No. 4502 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4502 has been discontinued.

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说明： Inhibits EGFR activation; also induces apoptosis
别名： 3,3-Diindolylmethane
化学名： 3,3'-Methylenediindole
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for DIM

DIM is an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.

技术数据 for DIM

分子量 246.31
公式 C17H14N2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1968-05-4
PubChem ID 10900930
InChI Key SHXKYUYEFDONQC-UHFFFAOYSA-N
Smiles C12=CC=CC=C1C(CC3=CC(C=CC=C4)=C4N3)=CN2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for DIM

参考文献是支持产品生物活性的出版物。

Kandala et al (2012) Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. J.Pharmacol.Exp.Ther. 341 24 PMID: 22205686

Kandala & Srivastava (2010) Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Mol.Pharmacol. 78 297 PMID: 20444961

Shorey et al (2012) 3,3'-diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One. 7 e34975 PMID: 22514694

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关键词: DIM, DIM supplier, Chk2, checkpoint, kinase, 2, activators, antiproliferatives, anticancer, chemotherapeutics, epidermal, growth, factor, receptors, EGFR, inhibitors, inhibits, pro-apoptotic, apoptosis, inducers, 3,3-diindolylmethane, 3,3-Diindolylmethane, Checkpoint, Control, Kinases, Cell, Cycle, Inhibitors, Other, Apoptosis, 4502, Tocris Bioscience

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DIM 的评论

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Determination of DIM suppression of EGFR.
By Anonymous on 12/14/2019
种属： Human

To determine whether DIM suppressed the activation of EGFR by activating phosphorylation, cells were treated with epidermal growth factor.

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Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.