主页 / 药理学 / Enzymes / Kinases / Cyclin-Dependent Kinases (CDKs) / CDK1 Subfamily (CDK1, CDK2 & CDK3) / CDK1 Subfamily Inhibitors / Dinaciclib

Dinaciclib

Cat. No. 7336 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective inhibitor of CDK2, CDK5, CDK1 and CDK9
别名： SCH 727965
化学名： (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Dinaciclib

Dinaciclib is a potent and selective inhibitor of CDK2, CDK5, CDK1 and CDK9 activity in vitro (IC50 values are 1, 1, 3 and 4 nM, respectively). The compound inhibits DNA replication by blocking thymidine DNA incorporation in A2780 cells (IC50 = 4 nM). Dinaciclib induces regression of established solid tumors in mouse models and shows antiviral activity against SARS-CoV-2 in vitro (Vero E6, IC50 = 0.127 μM; A549-ACE2, IC50 = 0.032 μM).

化合物库 for Dinaciclib

Dinaciclib is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Dinaciclib

分子量 396.5
公式 C21H28N6O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 779353-01-4
PubChem ID 46926350
InChI Key PIMQWRZWLQKKBJ-SFHVURJKSA-N
Smiles [O-][N+]1=CC=CC(CNC(N2N=C3)=CC(N4[C@@H](CCCC4)CCO)=NC2=C3CC)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Dinaciclib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.65 100
ethanol 7.93 20

制备储备液 for Dinaciclib

以下数据基于产品分子量 396.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.61 mL 25.22 mL
5 mM 0.5 mL 2.52 mL 5.04 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for Dinaciclib

参考文献是支持产品生物活性的出版物。

Parry et al (2010) Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor. Mol.Cancer Ther. 9 2344 PMID: 20663931

Bouhaddou et al (2020) The global phosphorylation landscape of SARS-CoV-2 infection. Cell 182 685 PMID: 32645325

If you know of a relevant reference for Dinaciclib, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 CDK1 Subfamily Inhibitors

关键词: Dinaciclib, Dinaciclib supplier, SCH727965, cyclin, dependent, kinase, inhibitors, inhibits, CDK2, CDK5, antiviral, DNA, replication, potent, selective, SARS-CoV-2, SCH, 727965, CDK1, Subfamily, Coronavirus, 7336, Tocris Bioscience

篇 Dinaciclib 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Dinaciclib 的引用文献。 您是否知道使用了 Tocris Dinaciclib 的优秀论文？ 请告知我们.

Dinaciclib 的评论

目前没有该产品的评论。 Be the first to review Dinaciclib and earn rewards!

Have you used Dinaciclib?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review