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DL 175

Cat. No. 7082 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective GPR84 agonist
化学名： 3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DL 175

DL 175 is a potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.

化合物库 for DL 175

DL 175 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for DL 175

分子量 299.75
公式 C17H14ClNO2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2487253-25-6
InChI Key FXOVKEUUTXBOJZ-UHFFFAOYSA-N
Smiles ClC1=C(C=CC=C2)C2=C(OCCC3=C[N+]([O-])=CC=C3)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DL 175

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.98 100
ethanol 29.98 100

制备储备液 for DL 175

以下数据基于产品分子量 299.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.34 mL 16.68 mL 33.36 mL
5 mM 0.67 mL 3.34 mL 6.67 mL
10 mM 0.33 mL 1.67 mL 3.34 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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参考文献 for DL 175

参考文献是支持产品生物活性的出版物。

Lucy et al (2019) A biased agonist at immunometabolic receptor GPR84 causes distinct functional effects in macrophages. ACS Chem.Biol 14 2055 PMID: 31465201

If you know of a relevant reference for DL 175, please let us know.

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关键词: DL 175, DL 175 supplier, DL175, GPR84, potent, selective, agonists, agonism, macrophages, monocytes, chemotaxis, phagocytosis, Free, Fatty, Acid, Receptors, 7082, Tocris Bioscience

1 篇 DL 175 的引用文献

引用文献是使用了 Tocris 产品的出版物。 DL 175 的部分引用包括：

Marsango et al (2022) Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands. J.Biol.Chem. 298 101932 PMID: 35427647

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