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(±)-5'-Chloro-5'-deoxy-ENBA

Cat. No. 3576 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Highly selective A1 agonist
化学名： N-Bicyclo[2.2.1]hept-2-yl-5'-chloro-5'-deoxyadenosine
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for (±)-5'-Chloro-5'-deoxy-ENBA

(±)-5'-Chloro-5'-deoxy-ENBA is a highly selective adenosine A1 receptor agonist (Ki values are 0.51, 1290, 1340 and 2740 nM at A1, A3, A2A and A2B receptors respectively). Reverses formalin-induced nocifensive behavior in mice; antinociceptive.

化合物库 for (±)-5'-Chloro-5'-deoxy-ENBA

(±)-5'-Chloro-5'-deoxy-ENBA is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for (±)-5'-Chloro-5'-deoxy-ENBA

分子量 379.84
公式 C17H22ClN5O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 103626-26-2
PubChem ID 42636897
InChI Key PVJGDYDNVNCGBT-STHLEMNDSA-N
Smiles O[C@@H]1[C@H](O)[C@@H](CCl)O[C@H]1N(C=N3)C2=C3C(NC4C5CCC(C5)C4)=NC=N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (±)-5'-Chloro-5'-deoxy-ENBA

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.98 100
ethanol 37.98 100

制备储备液 for (±)-5'-Chloro-5'-deoxy-ENBA

以下数据基于产品分子量 379.84。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.16 mL 26.33 mL
5 mM 0.53 mL 2.63 mL 5.27 mL
10 mM 0.26 mL 1.32 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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产品说明书 for (±)-5'-Chloro-5'-deoxy-ENBA

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for (±)-5'-Chloro-5'-deoxy-ENBA

参考文献是支持产品生物活性的出版物。

Trivedi et al (1989) N6-bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor. J.Med.Chem. 32 8 PMID: 2909748

Franchetti et al (2009) N6-cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice. J.Med.Chem. 52 2393 PMID: 19317449

If you know of a relevant reference for (±)-5'-Chloro-5'-deoxy-ENBA, please let us know.

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关键词: (±)-5'-Chloro-5'-deoxy-ENBA, (±)-5'-Chloro-5'-deoxy-ENBA supplier, highly, selective, A1, adenosines, receptors, agonists, (±)-5-Chloro-5-deoxy-ENBA, ENBA, Adenosine, Receptors, 3576, Tocris Bioscience

2 篇 (±)-5'-Chloro-5'-deoxy-ENBA 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (±)-5'-Chloro-5'-deoxy-ENBA 的部分引用包括：

Cuiying et al (2020) Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms. PLoS One 15 e0243986 PMID: 33326493

Wei et al (2021) Adenosine A2A Receptor Activation Enhances Blood-Tumor Barrier Permeability in a Rodent Glioma Model. Mol Cancer Res 19 2081-2095 PMID: 34521765

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(±)-5'-Chloro-5'-deoxy-ENBA 的评论

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Antinociceptive assay and for reducing the development of abnormal involuntary movements L-DOPA induced.
By Anonymous on 01/08/2018
分析类型： In Vivo
种属： Mouse
细胞系/组织： CHO cells

In the first work, we demonstrated that chronic systemic administration of 5′-chloro-5′-deoxy-(±)-ENBA (0.5 mg/kg, i.p.) reduced both mechanical allodynia and thermal hyperalgesia 3 and 7 days post-SNI, in a way prevented by DPCPX (3 mg/kg, i.p.), a selective A1 adenosine receptor antagonist, without exerting any significant change on the motor coordination or arterial blood pressure (Molecules. 2012, 17, 13712-13726. doi: 10.3390/molecules171213712).Then, the product has been used to clearly demonstrate that functionalA1ARs are expressed in microglia (Glia. 2014, 62,122-132. doi: 10.1002/glia.22592).In addition, we found that 5′Cl5′ d-(±)-ENBA, administered in combination with L-DOPA, reduced the development of abnormal involuntary movements. These results indicate the potential benefit of A1R agonists for the treatment of L-DOPA-induced dyskinesia and hyperkinetic disorders providing a mechanistic framework for the study of the interaction between DA and adenosine in the striatonigral system (Exp Neurol. 2014, 261, 733-43. doi: 10.1016/j.expneurol.2014.08.022).

the product has to be stored in the refrigerator (-20°C) otherwise (room temperature) decompose

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