(±)-Clopidogrel hydrochloride

Name: (±)-Clopidogrel hydrochloride
Brand: Tocris Bioscience
SKU: 2490
Rating: 4 (1 reviews)

Cat. No. 2490 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective P2Y₁₂ antagonist

别名： Plavix

化学名： Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (±)-Clopidogrel hydrochloride

(±)-Clopidogrel hydrochloride is a selective, high affinity P2Y₁₂ receptor antagonist (pK_i = 6.9 for hP2Y₁₂ receptor). Inhibits ADP-induced platelet aggregation; potent antithrombotic agent. Requires bioactivation, unlike PSB 0739.

Active Enantiomer also available.

技术数据 for (±)-Clopidogrel hydrochloride

分子量	358.28
公式	C₁₆H₁₆NO₂SCl.HCl
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	130209-90-4
PubChem ID	22386150
InChI Key	XIHVAFJSGWDBGA-UHFFFAOYSA-N
Smiles	Cl.COC(=O)C(N1CCC2=C(C1)C=CS2)C1=C(Cl)C=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (±)-Clopidogrel hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	35.83	100
	ethanol	35.83	100

制备储备液 for (±)-Clopidogrel hydrochloride

以下数据基于产品分子量 358.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.79 mL	13.96 mL	27.91 mL
5 mM	0.56 mL	2.79 mL	5.58 mL
10 mM	0.28 mL	1.4 mL	2.79 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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产品说明书 for (±)-Clopidogrel hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (±)-Clopidogrel hydrochloride

参考文献是支持产品生物活性的出版物。

Kugelgen (2006) Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol.Ther. 110 415 PMID: 16257449

Savi et al (2001) P2Y₁₂, a new platelet ADP receptor, target of clopid. Biochem.Biophys.Res.Comm. 283 379

Savi and Herbert (2005) Clopidogrel and ticlopidine: P2Y₁₂ adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin.Thromb.Haemostas. 31 174

If you know of a relevant reference for (±)-Clopidogrel hydrochloride, please let us know.

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Purinergic (P2Y) Receptors

关键词: (±)-Clopidogrel hydrochloride, (±)-Clopidogrel hydrochloride supplier, Selective, P2Y12, antagonists, Receptors, Purinergic, purinoceptors, p2yt, antagonises, inhibitors, inhibits, Plavix, P2Y, 2490, Tocris Bioscience

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P2Y12 antagonist.

By Anonymous on 09/20/2018

种属： Human

incubation and during assay

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.