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Submit Review(+)-Clopidogrel hydrogen sulfate
Description: Selective P2Y12 antagonist
Alternative Names: Plavix
Chemical Name: (S)-(+)-Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrogen sulfate
Purity: ≥99% (HPLC)
Biological Activity for (+)-Clopidogrel hydrogen sulfate
(+)-Clopidogrel hydrogen sulfate is a selective, high affinity P2Y12 receptor antagonist. Inhibits ADP-induced platelet aggregation and displays antithrombotic activity. Active enantiomer of (±)-clopidogrel hydrochloride (Cat. No. 2490). Requires bioactivation.
Technical Data for (+)-Clopidogrel hydrogen sulfate
| M. Wt | 419.9 |
| Formula | C16H16ClNO2S.H2SO4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 120202-66-6 |
| PubChem ID | 115366 |
| InChI Key | FDEODCTUSIWGLK-RSAXXLAASA-N |
| Smiles | OS(O)(=O)=O.COC(=O)[C@@H](N1CCC2=C(C1)C=CS2)C1=CC=CC=C1Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (+)-Clopidogrel hydrogen sulfate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 41.99 | 100 | |
| DMSO | 41.99 | 100 |
Preparing Stock Solutions for (+)-Clopidogrel hydrogen sulfate
The following data is based on the product molecular weight 419.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.91 mL | 23.82 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets for (+)-Clopidogrel hydrogen sulfate
References for (+)-Clopidogrel hydrogen sulfate
References are publications that support the biological activity of the product.
Kugelgen (2006) Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol.Ther. 110 415 PMID: 16257449
Reist et al (2000) Very low chiral inversion of clopid. in rats: a pharmacokinetic and mechanistic investigation. Drug Metab.Disp. 28 1405
Savi et al (2001) P2Y12, a new platelet ADP receptor, target of clopid. Biochem.Biophys.Res.Comm. 283 379
Savi and Herbert (2005) Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin.Thromb.Haemostas. 31 174
If you know of a relevant reference for (+)-Clopidogrel hydrogen sulfate, please let us know.
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Citations for (+)-Clopidogrel hydrogen sulfate
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.