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±-MF 094

Cat. No. 6718 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective USP30 inhibitor
化学名： N-(1-((5-(N-(tert-Butyl)sulfamoyl)naphthalen-1-yl)amino)-1-oxo-3-phenylpropan-2-yl)cyclohexanecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ±-MF 094

±-MF 904 is the racemate of MF 904, the S-enantiomer. The S-enantiomer is a selective USP30 (ubiquitin-specific-processing protease 30) inhibitor (IC50 = 120 nM). MF 094 increases protein ubiquitination and accelerates mitophagy.

技术数据 for ±-MF 094

分子量 535.7
公式 C30H37N3O4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2758431-95-5
PubChem ID 146503417
InChI Key DQXORJHBZHLLTE-UHFFFAOYSA-N
Smiles CC(C)(NS(=O)(C1=CC=CC2=C1C=CC=C2NC(C(NC(C3CCCCC3)=O)CC4=CC=CC=C4)=O)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ±-MF 094

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 26.78 50

制备储备液 for ±-MF 094

以下数据基于产品分子量 535.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 3.73 mL 18.67 mL 37.33 mL
2.5 mM 0.75 mL 3.73 mL 7.47 mL
5 mM 0.37 mL 1.87 mL 3.73 mL
25 mM 0.07 mL 0.37 mL 0.75 mL

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参考文献 for ±-MF 094

参考文献是支持产品生物活性的出版物。

Kluge et al (2018) Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg.Med.Chem.Lett. 28 2655 PMID: 29935771

Li and Liu et al (2020) Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors. Eur.J.Med.Chem. 191 112107 PMID: 32092586

If you know of a relevant reference for ±-MF 094, please let us know.

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关键词: (±)-MF 094, (±)-MF 094 supplier, MF094, racemate, USP30, inhibitors, inhibits, selective, ubiquitin, carboxyl-terminal, hydrolase, specific-processing, protease, mitophagy, ubiquitination, Deubiquitinating, Enzymes, 6718, Tocris Bioscience

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