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Submit ReviewDMAB-anabaseine dihydrochloride
Discontinued Product
2241 has been discontinued.
说明： Partial agonist at α7 nAChR; also α4β2 antagonist
化学名： 4-[(5,6-Dihydro[2,3'-bipyridin]-3(4H)-ylidene)methyl]-N,N-dimethylbenzenamine dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for DMAB-anabaseine dihydrochloride
Partial agonist at α7-containing neuronal nicotinic receptors and antagonist at α4β2 and other nicotinic receptors. Displays specific cognition-enhancing effects; improves long-term memory in rats.
技术数据 for DMAB-anabaseine dihydrochloride
| 分子量 | 364.32 |
| 公式 | C19H21N3.2HCl |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 154149-38-9 |
| PubChem ID | 16759167 |
| InChI Key | DHCNEWWWKHBASC-YNHPUKFJSA-N |
| Smiles | CN(C)C1=CC=C(/C=C2/C(C3=CN=CC=C3)=NCCC2)C=C1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for DMAB-anabaseine dihydrochloride
参考文献 for DMAB-anabaseine dihydrochloride
参考文献是支持产品生物活性的出版物。
Arendash et al (1995) Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res. 674 252 PMID: 7796104
Kem et al (1997) Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 283 979 PMID: 9399967
Stevens et al (1998) Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology 136 320 PMID: 9600576
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关键词: DMAB-anabaseine dihydrochloride, DMAB-anabaseine dihydrochloride supplier, Partial, agonists, α7, alpha7-containing, a7, receptors, antagonists, α4β2, a4b2, neuronal, nicotinic, Nicotinic, Receptors, Acetylcholine, nAChR, (a7), (a4b2), 2241, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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