Dolastatin 10 trifluoroacetate

Name: Dolastatin 10 trifluoroacetate
Brand: Tocris Bioscience
SKU: 3375

Cat. No. 3375 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3375 has been discontinued.

View all Microtubules products.

说明： Tubulin polymerization inhibitor

化学名： N,N-Dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazol)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl--valinamide trifluoroacetate

纯度： ≥95% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Dolastatin 10 trifluoroacetate

Dolastatin 10 trifluoroacetate is a tubulin polymerization inhibitor. Noncompetitively inhibits binding of radiolabeled vincristine to tubulin (K_i = 1.4 μM) and induces tubulin aggregation in vitro.

技术数据 for Dolastatin 10 trifluoroacetate

分子量	899.11
公式	C₄₂H₆₈N₆O₆S.CF₃CO₂H
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	2342568-65-2
PubChem ID	9810929
InChI Key	OFDNQWIFNXBECV-VFSYNPLYSA-N
Smiles	O=C(C[C@@H](OC)[C@@H](N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)[C@@H](C)CC)N1[C@@]([C@H](OC)[C@@H](C)C(N[C@@H](CC3=CC=CC=C3)C2=NC=CS2)=O)([H])CCC1.FC(C(O)=O)(F)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Dolastatin 10 trifluoroacetate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Dolastatin 10 trifluoroacetate

参考文献是支持产品生物活性的出版物。

Bai et al (1990) Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. J.Biol.Chem. 265 17141 PMID: 2211617

Bai et al (1995) Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions. Mol.Pharmacol. 47 965 PMID: 7746283

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