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Submit ReviewDQP 1105
说明： GluN2C/GluN2D-selective NMDA antagonist
化学名： 5-(4-Bromophenyl)-3-(1,2-dihydro-6-methyl-2-oxo-4-phenyl-3-quinolinyl)-4,5-dihydro-γ-oxo-1H-pyrazole-1-butanoic acid
纯度： ≥97% (HPLC)
生物活性 for DQP 1105
DQP 1105 is a noncompetitive NMDA receptor antagonist; displays over 50-fold selectivity for GluN2D- and GluN2C-containing receptors over GluN2B-, GluK2-, GluA1- and GluN2A-containing receptors (IC50 values are 2.7, 8.5, 121, 153, 198 and 206 μM, respectively). Reduces frequency of channel opening.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
化合物库 for DQP 1105
DQP 1105 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for DQP 1105
| 分子量 | 558.42 |
| 公式 | C29H24BrN3O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 380560-89-4 |
| PubChem ID | 2723792 |
| InChI Key | JIQFFACVQXXHMY-YDALLXLXSA-N |
| Smiles | O=C2C(C4=NN(C(CCC(O)=O)=O)C(C5=CC=C(Br)C=C5)C4)=C(C3=CC=CC=C3)C1=CC(C)=CC=C1N2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for DQP 1105
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 55.84 | 100 |
制备储备液 for DQP 1105
以下数据基于产品分子量 558.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.79 mL | 8.95 mL | 17.91 mL |
| 5 mM | 0.36 mL | 1.79 mL | 3.58 mL |
| 10 mM | 0.18 mL | 0.9 mL | 1.79 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
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产品说明书 for DQP 1105
参考文献 for DQP 1105
参考文献是支持产品生物活性的出版物。
Acker et al (2011) Mechanism for noncompetitive inhibition by novel GluN2C/D N-MthD.-aspartate receptor subunit-selective modulators. Mol.Pharmacol. 80 782 PMID: 21807990
If you know of a relevant reference for DQP 1105, please let us know.
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关键词: DQP 1105, DQP 1105 supplier, DQP1105, supplier, NMDAD, Glu2NC, antagonists, selective, noncompetitive, inhibitors, inhibits, NMDA, Receptors, 4491, Tocris Bioscience
2 篇 DQP 1105 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DQP 1105 的部分引用包括：
Brancaccio et al (2017) Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling. Neuron 93 1420 PMID: 28285822
Lozovaya et al (2014) Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model. Nat Commun 5 4563 PMID: 25081057
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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