E 64d

Cat. No. 4545 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Cathepsin inhibitor; interferes with autolysosomal digestion

化学名： (2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic acid ethyl ester

纯度： ≥98% (HPLC)

说明书

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for E 64d

E 64d is an inhibitor of cathepsins B and L; also thought to inhibit calpain. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with pepstatin A (Cat. No. 1190). Lysosome and cell permeable. Also inhibits entry of SARS-Cov-2 (COVID-19) into Caco-2 and Vero cells in combination with Camostat mesylate (Cat.No. 3193) in vitro.

技术数据 for E 64d

分子量	342.43
公式	C₁₇H₃₀N₂O₅
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	88321-09-9
PubChem ID	65663
InChI Key	SRVFFFJZQVENJC-IHRRRGAJSA-N
Smiles	O=[C@@](N[C@H]([C@](NCCC(C)C)=O)CC(C)C)[C@H]1O[C@@H]1C(OCC)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for E 64d

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	ethanol	6.85	20

制备储备液 for E 64d

以下数据基于产品分子量 342.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	14.6 mL	73.01 mL	146.02 mL
1 mM	2.92 mL	14.6 mL	29.2 mL
2 mM	1.46 mL	7.3 mL	14.6 mL
10 mM	0.29 mL	1.46 mL	2.92 mL

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产品说明书 for E 64d

分析证书/产品说明书

化学品安全技术说明书

参考文献 for E 64d

参考文献是支持产品生物活性的出版物。

Kim et al (2008) Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 4 659 PMID: 18424912

Sato et al (2007) Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 67 9677 PMID: 17942897

Tanada et al (2005) Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 1 84 PMID: 16874052

Wilcox and Mason (1992) Inhibition of cysteine proteinases in lysosomes and whole cells. Biochem.J. 285 495 PMID: 1637341

Hoffmann et al (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor. Cell 181 271 PMID: 32142651

If you know of a relevant reference for E 64d, please let us know.

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