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Ec2la

Cat. No. 6832 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Positive allosteric modulator of CB2 receptors; active in vivo
化学名： N-[5-Bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]cycloheptanecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ec2la

Ec2la is a CB2 receptor positive allosteric modulator. Enhances CP 55940 (Cat. No. 0949) and 2-Arachidonylglycerol (Cat. No. 1298)-stimulated binding of [35S]GTPγS to CB2 receptors, but has no effect in the absence of agonist. Exhibits antinociceptive effects in an animal model of neuropathic pain.

化合物库 for Ec2la

Ec2la is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Ec2la

分子量 435.33
公式 C21H24BrFN2O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2244579-87-9
PubChem ID 137553165
InChI Key NSGDYZCDUPSTQT-UHFFFAOYSA-N
Smiles CC1=C(C(N(C=C1Br)CC2=CC=C(C=C2)F)=O)NC(C3CCCCCC3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ec2la

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 8.71 20

制备储备液 for Ec2la

以下数据基于产品分子量 435.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 11.49 mL 57.43 mL 114.86 mL
1 mM 2.3 mL 11.49 mL 22.97 mL
2 mM 1.15 mL 5.74 mL 11.49 mL
10 mM 0.23 mL 1.15 mL 2.3 mL

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参考文献 for Ec2la

参考文献是支持产品生物活性的出版物。

Gado et al (2019) Identification of the first synthetic allosteric modulator of the CB2 receptors and evidence of its efficacy for neuropathic pain relief. J.Med.Chem. 62 276 PMID: 29990428

If you know of a relevant reference for Ec2la, please let us know.

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关键词: Ec2la, Ec2la supplier, CB2, positive, allosteric, modulator, PAM, cannabinoid, neuropathic, pain, Ec21a, Ec2Ia, Receptors, 6832, Tocris Bioscience

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该领域的文献

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