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Echinomycin

Cat. No. 5520 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Highly potent and selective HIF-1α inhibitor
别名： Quinomycin A
化学名： N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Echinomycin

Echinomycin is a highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells. Eradicates mouse lymphomas and human AML xenografts by eliminating CSCs.

技术数据 for Echinomycin

分子量 1101.26
公式 C51H64N12O12S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 512-64-1
PubChem ID 91826096
InChI Key AUJXLBOHYWTPFV-LDUXBRJQSA-N
Smiles O=C(N[C@](C(N[C@H](C(N(C)[C@@](C(SC[C@@](N(C)C([C@H](C)NC4=O)=O)([H])C3=O)SC)([H])C(N(C)[C@@H]([C@@H](C)C)C(OC[C@]([H])4NC(C5=CN=C(C=CC=C6)C6=N5)=O)=O)=O)=O)C)=O)([H])COC([C@H]([C@@H](C)C)N3C)=O)C2=NC1=CC=CC=C1N=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Echinomycin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 5 5

制备储备液 for Echinomycin

以下数据基于产品分子量 1101.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 18.16 mL 90.81 mL 181.61 mL
0.25 mM 3.63 mL 18.16 mL 36.32 mL
0.5 mM 1.82 mL 9.08 mL 18.16 mL
2.5 mM 0.36 mL 1.82 mL 3.63 mL

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产品说明书 for Echinomycin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Echinomycin

参考文献是支持产品生物活性的出版物。

Wang et al (2011) Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 8 399 PMID: 21474104

Kwon et al (2011) Physical and functional interactions between Runx2 and HIF-1α induce vascular endothelial growth factor gene expression. J.Cell.Biochem. 112 3582 PMID: 21793044

Kong et al (2005) Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 65 9047 PMID: 16204079

If you know of a relevant reference for Echinomycin, please let us know.

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关键词: Echinomycin, Echinomycin supplier, Highly, potent, selective, HIF-1α, inhibitors, inhibits, cancer, stem, cells, VEGF, lymphomas, Quinomycin, A, Hypoxia, Inducible, Factors, 5520, Tocris Bioscience

1 篇 Echinomycin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Echinomycin 的部分引用包括：

David H et al (2020) Oxygen Tension and the VHL-Hif1α Pathway Determine Onset of Neuronal Polarization and Cerebellar Germinal Zone Exit. Neuron 106 607-623.e5 PMID: 32183943

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