Edaglitazone

Pricing Availability   Qty
说明: Potent and selective PPARγ agonist; antidiabetic
别名: R 483,BM 131258
化学名: 5-[[4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]benzo[b]thien-7-yl]methyl]-2,4-thiazolidinedione
纯度: ≥98% (HPLC)
说明书
引用文献 (1)
评论

生物活性 for Edaglitazone

Edaglitazone is a potent and selective PPARγ agonist (EC50 values are 35.6 and 1053 nM for PPARγ and PPARα cofactor recruitment respectively. Enhances insulin sensitivity in obese, but not lean, rats. Antidiabetic and orally bioavailable.

化合物库 for Edaglitazone

Edaglitazone is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Edaglitazone

分子量 464.56
公式 C24H20N2O4S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 213411-83-7
PubChem ID 9825701
InChI Key HAAXAFNSRADSMK-UHFFFAOYSA-N
Smiles CC(OC(C5=CC=CC=C5)=N4)=C4CCOC(C3=C2SC=C3)=CC=C2CC1C(NC(S1)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Edaglitazone

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 100

制备储备液 for Edaglitazone

以下数据基于产品分子量 464.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.76 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Dilution Calculator

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参考文献 for Edaglitazone

参考文献是支持产品生物活性的出版物。

Fürnsinn et al (1999) Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism. Br. J. Pharmacol. 128 1141 PMID: 10578125

Dietz et al (2012) Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors. ChemMedChem 7 1101 PMID: 22489042


If you know of a relevant reference for Edaglitazone, please let us know.

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关键词: Edaglitazone, Edaglitazone supplier, potent, selective, peroxisome, proliferator-activated, receptors, PPARgamma, PPARg, PPARγ, agonists, diabetes, antidiabetics, R483, BM131258, insulin, sensitizers, R, 483, BM, 131258, Receptors, 4784, Tocris Bioscience

1 篇 Edaglitazone 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Edaglitazone 的部分引用包括:

Hui et al (2022) An obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABAA receptor. Cell Death Dis 13 356 PMID: 35436993


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