EG 00229 trifluoroacetate

Cat. No. 6986 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

化学名： N²-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine trifluoroacetate

纯度： ≥98% (HPLC)

引用文献 (3)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for EG 00229 trifluoroacetate

EG 00229 trifluoroacetate is a neuropilin 1 (NRP1) antagonist; inhibits VEGFA binding to the NRP1 b1 CendR binding pocket. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Inhibits binding of CendR motif in S1 protein of SARS-CoV-2 to NRP1, and reduces efficiency of SARS-CoV-2 infection in Caco-2 cells.

化合物库 for EG 00229 trifluoroacetate

EG 00229 trifluoroacetate is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for EG 00229 trifluoroacetate

分子量	611.59
公式	C₁₇H₁₉N₇O₅S₃.CF₃CO₂H
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1210945-69-9
PubChem ID	45142253
InChI Key	ZYQBITUOSRZDTG-MERQFXBCSA-N
Smiles	O=S(C1=CC=CC2=NSN=C12)(NC3=C(C(N[C@H](C(O)=O)CCCNC(N)=N)=O)SC=C3)=O.FC(F)(F)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EG 00229 trifluoroacetate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	61.16	100
	2eq. NaOH	61.16	100

制备储备液 for EG 00229 trifluoroacetate

以下数据基于产品分子量 611.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.64 mL	8.18 mL	16.35 mL
5 mM	0.33 mL	1.64 mL	3.27 mL
10 mM	0.16 mL	0.82 mL	1.64 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for EG 00229 trifluoroacetate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for EG 00229 trifluoroacetate

参考文献是支持产品生物活性的出版物。

Jarvis et al (2010) Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J.Med.Chem. 53 2215 PMID: 20151671

Daly et al (2020) Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science 370 861 PMID: 33082294

If you know of a relevant reference for EG 00229 trifluoroacetate, please let us know.

按标靶查看相关产品

关键词: EG 00229 trifluoroacetate, EG 00229 trifluoroacetate supplier, EG00229, trifluoroacetate, EG, 00229, TFA, neuropilin, receptor, antagonists, VEGFA, receptors, nrp1, Vascular, endothelial, growth, factor, SARS-CoV-2, viral, cell, entry, VEGFR, Coronavirus, 6986, Tocris Bioscience

3 篇 EG 00229 trifluoroacetate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 EG 00229 trifluoroacetate 的部分引用包括：

Daly et al (2020) Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science 370 861 PMID: 33082294

Curtis A et al (2021) Novel Compounds Targeting Neuropilin Receptor 1 with Potential To Interfere with SARS-CoV-2 Virus Entry. ACS Chem Neurosci 12 1299-1312 PMID: 33787218

Rajesh et al (2021) SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia. Pain 162 243-252 PMID: 33009246

您是否知道使用了 Tocris EG 00229 trifluoroacetate 的优秀论文？请告知我们.