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EG 00229

Cat. No. 4931 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

This product has been withdrawn from sale and is superseded by EG 00229 trifluoroacetate (Cat. No. 6986)
说明： Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1
化学名： N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for EG 00229

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to the NRP1 b1 domain. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Increases chemo-sensitivity of A549 cells in combination with Taxol (Cat. No. 1097). Blocks pro-tumorigenic M2 polarization in glioma-associated microglia and macrophages and reduces tumor growth and vascularization in NSG mice.

技术数据 for EG 00229

分子量 497.57
公式 C17H19N7O5S3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1018927-63-3
PubChem ID 44631827
InChI Key ZWWMEDURALZMEV-NSHDSACASA-N
Smiles O=S(C1=CC=CC2=NSN=C12)(NC3=C(C(N[C@H](C(O)=O)CCCNC(N)=N)=O)SC=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for EG 00229

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for EG 00229

参考文献是支持产品生物活性的出版物。

Jarvis et al (2010) Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J.Med.Chem. 53 2215 PMID: 20151671

Grun et al (2016) VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors. Oncogene. 35 4379 PMID: 26804163

Miyauchi et al (2016) Ablation of Neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression. Oncotarget. 7 9801 PMID: 26755653

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关键词: EG 00229, EG 00229 supplier, EG00229, antagonists, VEGFA, receptors, neuropilin, nrp1, taxol, increases, chemo, sensitivity, Vascular, endothelial, growth, factor, VEGFR, 4931, Tocris Bioscience

1 篇 EG 00229 的引用文献

引用文献是使用了 Tocris 产品的出版物。 EG 00229 的部分引用包括：

Nissen et al (2013) Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. J.Neurochem. 127 394 PMID:  24033337

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for EG 00229

VEGF Signaling Pathway

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.