EHNA hydrochloride

Cat. No. 1261 11 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Adenosine deaminase inhibitor

化学名： erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride

纯度： ≥98% (HPLC)

引用文献 (11)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for EHNA hydrochloride

EHNA hydrochloride is a selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC₅₀ = 0.8 - 4 μM). Also a potent inhibitor of adenosine deaminase. Suppresses spontaneous differentiation of human ESCs in feeder-free conditions. Also prevents directed neuronal differentiation.

化合物库 for EHNA hydrochloride

EHNA hydrochloride is also offered as part of the Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for EHNA hydrochloride

分子量	313.83
公式	C₁₄H₂₃N₅O.HCl
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	58337-38-5
PubChem ID	11056106
InChI Key	VVDXNJRUNJMYOZ-DHXVBOOMSA-N
Smiles	NC1=NC=NC2=C1N=CN2[C@@H](CCCCCC)[C@H](O)C.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EHNA hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	31.38	100
	ethanol	31.38	100
	DMSO	31.38	100

制备储备液 for EHNA hydrochloride

以下数据基于产品分子量 313.83。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.19 mL	15.93 mL	31.86 mL
5 mM	0.64 mL	3.19 mL	6.37 mL
10 mM	0.32 mL	1.59 mL	3.19 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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产品说明书 for EHNA hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for EHNA hydrochloride

参考文献是支持产品生物活性的出版物。

Bessodes et al (1982) Effect of chirality in erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) on adenosine deaminase inhibition. Biochem.Pharmacol. 31 879 PMID: 7082355

Michie et al (1996) Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T-cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. Cell.Signal. 8 97 PMID: 8730511

Podzuweit et al (1995) Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl)adenine. Cell.Signal. 7 733 PMID: 8519602

If you know of a relevant reference for EHNA hydrochloride, please let us know.

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关键词: EHNA hydrochloride, EHNA hydrochloride supplier, PDE2, inhibitors, inhibits, adenosines, deaminases, Phosphodiesterases, Deaminases, Other, Adenosine, Stem, Cell, Proliferation, 1261, Tocris Bioscience