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EIPA

Cat. No. 3378 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibits TRPP3-mediated currents; also inhibits the Na+/H+ exchanger (NHE)
别名： Ethylisopropyl amiloride
化学名： 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for EIPA

EIPA is a TRPP3 channel inhibitor (IC50 = 10.5 μM). Inhibits the Na+/H+ exchanger (NHE). Derivative of amiloride (Cat. No. 0890).

化合物库 for EIPA

EIPA is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for EIPA

分子量 299.76
公式 C11H18ClN7O
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1154-25-2
PubChem ID 1795
InChI Key QDERNBXNXJCIQK-UHFFFAOYSA-N
Smiles ClC1=C(N(C(C)C)CC)N=C(N)C(C(NC(N)=N)=O)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EIPA

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.98 100

制备储备液 for EIPA

以下数据基于产品分子量 299.76。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.34 mL 16.68 mL 33.36 mL
5 mM 0.67 mL 3.34 mL 6.67 mL
10 mM 0.33 mL 1.67 mL 3.34 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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产品说明书 for EIPA

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for EIPA

参考文献是支持产品生物活性的出版物。

Dai et al (2007) Inhibition of TRPP3 channel by amil. and analogs. Mol.Pharmacol. 72 1576 PMID: 17804601

Horinouchi et al (2008) Functional role of Na+/H+ exchanger in Ca2+ influx mediated via human endothelin type A receptor stably expressed in Chinese hamster ovary cells. J.Pharm.Sci. 107 456 PMID: 18678984

If you know of a relevant reference for EIPA, please let us know.

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关键词: EIPA, EIPA supplier, sodium, hydrogen, exchangers, NHE-1, NHE, blockers, inhibitors, inhibits, TRPP3, antagonists, Amiloride, ethylisopropyl, amiloride, Ethylisopropyl, Na+/H+, Exchanger, TRPP, 3378, Tocris Bioscience

2 篇 EIPA 的引用文献

引用文献是使用了 Tocris 产品的出版物。 EIPA 的部分引用包括：

Knudsen et al (2019) Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production. Cell Metab 29 430 PMID: 30415925

Neubert et al (2020) NCX1 Represents an Ionic Na+ Sensing Mechanism in Macrophages. PloS Biol 18 PMID: 32569301

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EIPA 的评论

平均评分: 5 (Based on 1 Review.)

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EIPA (Cat. No. 3378).
By Clara Lubeseder-Martellato on 11/12/2021
分析类型： In Vitro
种属： Mouse
细胞系/组织： prmouse pancreatic tumor cell lines

EIPA was added to the cells at 25 uM for 48 hours

PMID: 32434991