ELA-11 (human)

Name: ELA-11 (human)
Brand: Tocris Bioscience
SKU: 6698

Cat. No. 6698 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6698 has been discontinued.

View all Apelin Receptors products.

说明： High affinity apelin agonist

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for ELA-11 (human)

High affinity apelin receptor agonist (K_i = 14 nM). Bioactive fragment of ELA-32 (Cat. No. 6291). Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.

技术数据 for ELA-11 (human)

分子量	1283.57
公式	C₅₈H₉₀N₁₆O₁₃S₂
序列	CMPLHSRVPFP
储存	Store at -20°C
CAS Number	1784687-32-6
PubChem ID	127043376
InChI Key	XXKPNJFJXZBRMX-HDKAIKTRSA-N
Smiles	[H]N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for ELA-11 (human)

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ELA-11 (human)

参考文献是支持产品生物活性的出版物。

Yang et al (2017) Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension. Circulation 135 1160 PMID: 28137936

Murza et al (2016) Discovery and structure-activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions. J.Med.Chem. 59 2962 PMID: 26986036

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关键词: ELA-11 (human), ELA-11 (human) supplier, high, affinity, apelin, APJ, receptor, agonists, agonism, Elabela, fragment, Apelin, Receptors, 6698, Tocris Bioscience

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