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ELA-14 (human)

Cat. No. 6293 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6293 has been discontinued.

View all Apelin Receptors products.
说明： Potent apelin agonist; bioactive fragment of ELA-32 (Cat. No. 6291)
别名： ELA (19-32) (human),ELABELA
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for ELA-14 (human)

ELA-14 (human) is a potent apelin (APJ) receptor agonist (Ki = 0.93 nM). Bioactive fragment of ELA-32 (Cat. No. 6291). Activates Gαi1 pathway and β-arrestin-2 recruitment. Reduces arterial pressure in rat hearts. Active in vivo.

ELA-14 negative control (Cat.No. 6294) also available.

许可信息

Sold under agreement from the Agency for Science, Technology and Research (A*STAR), ETPL, and affiliates including the Institute of Medical Biology.

技术数据 for ELA-14 (human)

分子量 1707.03
公式 C75H119N25O17S2
序列 XRRCMPLHSRVPFP

(Modifications: X = Glp)
储存 Store at -20°C
CAS Number 1886973-05-2
PubChem ID 127043902
InChI Key LKYSPGTYQNANFL-GYVBEWGNSA-N
Smiles CSCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for ELA-14 (human)

参考文献是支持产品生物活性的出版物。

Murza et al (2016) Discovery and structure-activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions. J.Med.Chem. 59 2962 PMID: 26986036

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关键词: ELA-14 (human), ELA-14 (human) supplier, Apelin, receptor, agonist, agonism, APJ, ELABELA, analog, beta-arrestin-2, b-arrestin-2, β-arrestin-2, Gail, Galphail, Gαil, blood, pressure, active, in, vivo, ELA, (19-32), (human), Receptors, 6293, Tocris Bioscience

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