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EM 163

Cat. No. 7010 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： TIR-TIR interaction inhibitor
化学名： 1-Methyl-2,5-bis[[[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl](3-phenylpropyl)amino]carbonyl]pyridinium iodide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for EM 163

EM 163 is a TIR-TIR interaction inhibitor, that is a TIR (Toll/ interleukin-1 receptor) domain peptidomimetic of MyD88 protein. EM 163 targets TIR domains in IL-1 receptors blocking the interaction with MyD88. EM 163 inhibits staphylococcal enterotoxin B (SEB)-induced inflammatory cytokine production in vivo. EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocks the activation of p38 and the inhibitory effects of IL-1β on protein synthesis triggered by chemically-induced long-term potentiation (LTP).

技术数据 for EM 163

分子量 849.9
公式 C44H60IN5O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1206480-93-4
PubChem ID 44602511
InChI Key WJCJDZIXEVJIKZ-OFUZFLEOSA-M
Smiles CC([C@@H](C(N1CCCC1)=O)N(C(C2=C[N+](C)=C(C(N([C@H](C(N3CCCC3)=O)C(C)C)CCCC4=CC=CC=C4)=O)C=C2)=O)CCCC5=CC=CC=C5)C.[I-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EM 163

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 84.99 100

制备储备液 for EM 163

以下数据基于产品分子量 849.9。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.18 mL 5.88 mL 11.77 mL
5 mM 0.24 mL 1.18 mL 2.35 mL
10 mM 0.12 mL 0.59 mL 1.18 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

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参考文献 for EM 163

参考文献是支持产品生物活性的出版物。

Prieto et al (2019) Inhibition of LTP-induced translation by IL-1β reduces the level of newly synthesized proteins in hippocampal dendrites. ACS Chem.Neurosci. 20 1197 PMID: 30695637

Kissner et al (2012) Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88. PLoS One 7 e40773 PMID: 22848400

Lucas and Maes (2013) Role of the toll like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway. Mol.Neurobiol. 48 190 PMID: 23436141

If you know of a relevant reference for EM 163, please let us know.

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关键词: EM 163, EM 163 supplier, EM163, inhibitors, inhibits, Cytokines, cytokines, MyD88, anti-inflammatory, interleukin-1, TIR, IL-1, Cytokine, Receptors, 7010, Tocris Bioscience

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