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EN6

Cat. No. 7474 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： H+-ATPase activator; activates autophagy; inactivates mTORC1 signaling
化学名： N-[4-Fluoro-3-[(1-oxo-2-propen-1-yl)amino]phenyl]-1-(2-fluorophenyl)-1H-pyrazole-4-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for EN6

EN6 is an activator of lysosomal vacuolar H+ ATPase (v-ATPase). EN6 covalently binds to the catalytic subunit of v-ATPase leading to increased acidification of lysosomes, inactivation of mTORC1 signaling and activation of autophagy in vivo. EN6 triggers entosis and promotes clearance of TDP43 protein aggregates in vitro.

技术数据 for EN6

分子量 368.34
公式 C19H14F2N4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1808714-73-9
PubChem ID 99640033
InChI Key SUSXQEYPNDORDQ-UHFFFAOYSA-N
Smiles O=C(C=C)NC1=CC(=CC=C1F)NC(=O)C=2C=NN(C2)C=3C=CC=CC3F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EN6

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 3.68 10

制备储备液 for EN6

以下数据基于产品分子量 368.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 27.15 mL 135.74 mL 271.49 mL
0.5 mM 5.43 mL 27.15 mL 54.3 mL
1 mM 2.71 mL 13.57 mL 27.15 mL
5 mM 0.54 mL 2.71 mL 5.43 mL

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参考文献 for EN6

参考文献是支持产品生物活性的出版物。

Chung et al (2019) Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat.Chem.Biol. 15 776 PMID: 31285595

Su et al (2021) Role and dynamics of vacuolar pH during cell-in-cell mediated death. Cell Death Dis. 12 119 PMID: 33483474

If you know of a relevant reference for EN6, please let us know.

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关键词: EN6, EN6 supplier, EN6, activators, activates, autophagy, mTORC1signaling, lysosomes, lysosomal, vacuolar, H+, ATPases, entosis, v-ATPase, mTORC1, Autophagy, H+-ATPase, 7474, Tocris Bioscience

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