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Submit ReviewEpothilone B
说明： Microtubule stabilization agent; promotes tubulin polymerization
别名： Patupilone
化学名： (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
纯度： ≥98% (HPLC)
生物活性 for Epothilone B
Epothilone B is a microtubule stabilization agent that promotes tubulin polymerization and induces G2-M cell cycle arrest (EC50 = 32 nM in HeLa cells). Inhibits proliferation of human carcinoma cell lines in vitro, including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent cytotoxicity in MCF-7 and A549 cells (EC50 values are 0.3 and 2.7 nM respectively). Inhibits growth of HCT-15 tumors in mice in vivo.
技术数据 for Epothilone B
| 分子量 | 507.68 |
| 公式 | C27H41NO6S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 152044-54-7 |
| PubChem ID | 448013 |
| InChI Key | QXRSDHAAWVKZLJ-PVYNADRNSA-N |
| Smiles | CC1=NC(/C=[C@](C)/[C@@H](OC2=O)C[C@H]3[C@@](O3)(C)CCC[C@H](C)[C@H](O)[C@H](C([C@@](C)(C)[C@@H](O)C2)=O)C)=CS1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Epothilone B
参考文献 for Epothilone B
参考文献是支持产品生物活性的出版物。
Altmann et al (2000) Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity. Biochim.Biophys.Acta 1470 M79 PMID: 10799747
O'Reilly et al (2008) Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo. Cancer Chemother.Pharmacol. 62 1045 PMID: 18301895
Narvi et al (2013) Altered TUBB3 expression contributes to the epothilone response of mitotic cells. Br.J.Cancer 108 82 PMID: 23321512
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets