主页 / 药理学 / GPCRs / 7-TM Receptors / Trace Amine 1 Receptor / Trace Amine 1 Receptor Antagonists / EPPTB

EPPTB

Cat. No. 4518 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Trace amine 1 (TA1) receptor antagonist; also displays inverse agonism
化学名： N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for EPPTB

EPPTB is a trace amine 1 (TA1) receptor antagonist/inverse agonist; exhibits a higher potency at the mouse TA1 receptor than the rat and human TA1 receptors (IC50 values are 27.5, 4539 and 7487 nM, respectively). Blocks the TA1 receptor-mediated activation of an inwardly rectifying K+ current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area. Increases DA potency at the D2 receptor. Also displays inverse agonism, reducing basal cAMP levels in vitro (IC50 = 19 nM).

化合物库 for EPPTB

EPPTB is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for EPPTB

分子量 378.39
公式 C20H21F3N2O2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1110781-88-8
PubChem ID 25175634
InChI Key KLFVWQCQUXXLOU-UHFFFAOYSA-N
Smiles O=C(NC3=CC(OCC)=CC=C3)C1=CC(C(F)(F)F)=C(N2CCCC2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EPPTB

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.84 100
ethanol 37.84 100

制备储备液 for EPPTB

以下数据基于产品分子量 378.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.21 mL 26.43 mL
5 mM 0.53 mL 2.64 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for EPPTB

参考文献是支持产品生物活性的出版物。

Bradaia et al (2009) The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in DArgic neurons of the mesolimbic system. Proc.Natl.Acad.Sci.U.S.A. 106 20081 PMID: 19892733

If you know of a relevant reference for EPPTB, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Trace Amine 1 Receptor Antagonists

关键词: EPPTB, EPPTB supplier, Parkinson's, disease, trace, amine-associated, receptors, 1, TAAR1, antagonists, dopamine, neurons, neurones, TA1, Trace, Amine, Receptor, 4518, Tocris Bioscience

篇 EPPTB 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 EPPTB 的引用文献。 您是否知道使用了 Tocris EPPTB 的优秀论文？ 请告知我们.

EPPTB 的评论

平均评分: 2 (Based on 1 Review.)

5 星
0%
4 星
0%
3 星
0%
2 星
100%
1 星
0%

Have you used EPPTB?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Only Specific to mouse TAAR1.
By Alex Voisey on 12/31/2019
分析类型： In Vitro
种属： Rat

1-5 uM in organ bath for rat isolated aortic rings

only use for mouse tissues, all publications using this product are in mice

review image

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.