EPZ 004777

Cat. No. 5567 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Highly potent DOT1L inhibitor

化学名： 7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

纯度： ≥98% (HPLC)

引用文献 (1)

实验方案 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for EPZ 004777

EPZ 004777 is a highly potent DOT1L inhibitor (IC₅₀ = 0.4 nM). Exhibits >1000-fold selectivity for DOT1L over a panel of other methyltransferases. Selectively inhibits proliferation and induces apoptosis of MLL-rearranged cells in vitro. Prolongs survival in a MLL xenograft mouse model. Enhances efficiency of Yamanaka-factor factor reprogramming of fibroblasts by 3-4-fold.

For more information about how EPZ 004777 may be used, see our protocol:

Highly Efficient Generation of CiPSCs from MEFs

许可信息

Sold under license from Epizyme, Inc.

External Portal Information for EPZ 004777

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of EPZ004777 is reviewed on the chemical probes website.

化合物库 for EPZ 004777

EPZ 004777 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for EPZ 004777

分子量	539.67
公式	C₂₈H₄₁N₇O₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1338466-77-5
PubChem ID	56962336
InChI Key	WXRGFPHDRFQODR-ICLZECGLSA-N
Smiles	NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CN(CCCNC(NC4=CC=C(C(C)(C)C)C=C4)=O)C(C)C)O3)C=C2)=NC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for EPZ 004777

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	53.97	100
	ethanol	53.97	100

制备储备液 for EPZ 004777

以下数据基于产品分子量 539.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.26 mL	18.53 mL
5 mM	0.37 mL	1.85 mL	3.71 mL
10 mM	0.19 mL	0.93 mL	1.85 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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产品说明书 for EPZ 004777

分析证书/产品说明书

化学品安全技术说明书

参考文献 for EPZ 004777

参考文献是支持产品生物活性的出版物。

Yu et al (2012) Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat.Commun. 3 1288 PMID: 23250418

Onder et al (2012) Chromatin-modifying enzymes as modulators of reprogramming. Nature 483 598 PMID: 22388813

If you know of a relevant reference for EPZ 004777, please let us know.

按标靶查看相关产品

关键词: EPZ 004777, EPZ 004777 supplier, EPZ004777, highly, potent, DOT1L, methyltransferases, histones, inhibitors, inhibits, HMTs, MLL, leukemia, mll-rearranged, H3K79me, Lysine, Methyltransferases, Other, Stem, Cell, Reprogramming, 5567, Tocris Bioscience

1 篇 EPZ 004777 的引用文献

引用文献是使用了 Tocris 产品的出版物。 EPZ 004777 的部分引用包括：

Ebrahimi et al (2019) Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming. Nat.Chem.Biol 15 519 PMID: 30962627

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EPZ 004777 实验方案

以下实验方案包含使用 EPZ 004777（目录编号 5567）的更多信息。

Highly Efficient Generation of CiPSCs from MEFs