Erlotinib Hydrochloride

Cat. No. 7194 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, reversible EGFR tyrosine kinase inhibitor

化学名： N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Erlotinib Hydrochloride

Erlotinib hydrochloride is a reversible, potent EGFR tyrosine kinase inhibitor (IC₅₀ = 2 nM); it reduces EGFR autophosphorylation in intact tumor cells (IC₅₀ = 20 nM). Erlotinib is selective for cell lines showing PC-9 and H3255 mutations (IC₅₀ values are 7 and 12 nM, respectively, sparing wild-type and T790 mutant EGFR. Erlotinib shows antiproliferative effects in cancer cell lines in vitro and promotes differentiation of urothelial organoids. Orally bioavailable.

化合物库 for Erlotinib Hydrochloride

Erlotinib Hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Erlotinib Hydrochloride

分子量	429.9
公式	C₂₂H₂₃N₃O₄.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	183319-69-9
PubChem ID	176871
InChI Key	GTTBEUCJPZQMDZ-UHFFFAOYSA-N
Smiles	Cl.C#CC1=CC=CC(=C1)NC=2N=CN=C3C=C(OCCOC)C(OCCOC)=CC32

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Erlotinib Hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	8.6	20

制备储备液 for Erlotinib Hydrochloride

以下数据基于产品分子量 429.9。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	11.63 mL	58.15 mL	116.31 mL
1 mM	2.33 mL	11.63 mL	23.26 mL
2 mM	1.16 mL	5.82 mL	11.63 mL
10 mM	0.23 mL	1.16 mL	2.33 mL

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产品说明书 for Erlotinib Hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Erlotinib Hydrochloride

参考文献是支持产品生物活性的出版物。

Santos et al (2019) Urothelial organoids originating from Cd49f^high mouse stem cells display Notch-dependent differentiation capacity. Nat.Commun. 10 PMID: 31562298

Moyer et al (1997) Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 57 4838 PMID: 9354447

If you know of a relevant reference for Erlotinib Hydrochloride, please let us know.

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