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Escitalopram oxalate

Cat. No. 4796 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective serotonin reuptake inhibitor (SSRI)
化学名： (+)-(S)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile oxalate
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Escitalopram oxalate

Escitalopram oxalate is a selective 5-HT reuptake inhibitor (Ki values are 0.89, 8150, and 10500 nM for serotonin, noradrenalin, and dopamine transporters respectively). Escitalopram oxalate is an S-enantiomer and eutomer of citalopram (Cat. No. 1427).

化合物库 for Escitalopram oxalate

Escitalopram oxalate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Escitalopram oxalate

分子量 414.43
公式 C20H21FN2O.C2H2O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 219861-08-2
PubChem ID 146571
InChI Key KTGRHKOEFSJQNS-BDQAORGHSA-N
Smiles FC(C=C3)=CC=C3[C@]1(CCCN(C)C)OCC2=C1C=CC(C#N)=C2.OC(C(O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Escitalopram oxalate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 20.72 50
DMSO 41.44 100

制备储备液 for Escitalopram oxalate

以下数据基于产品分子量 414.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.06 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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产品说明书 for Escitalopram oxalate

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Escitalopram oxalate

参考文献是支持产品生物活性的出版物。

Zhang et al (2010) Structure-activity relationships for a novel series of cital. (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. J.Med.Chem. 53 6112 PMID: 20672825

If you know of a relevant reference for Escitalopram oxalate, please let us know.

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关键词: Escitalopram oxalate, Escitalopram oxalate supplier, Selective, serotonin, reuptake, inhibitors, inhibits, SSRI, SERT, 5-HT, Transporters, 4796, Tocris Bioscience

4 篇 Escitalopram oxalate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Escitalopram oxalate 的部分引用包括：

William C et al (2021) Psychedelic-inspired drug discovery using an engineered biosensor. Cell 184 2779-2792.e18 PMID: 33915107

Il-Whan et al (2017) Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells. Korean J Physiol Pharmacol 21 415-421 PMID: 28706455

Lu et al (2016) Generation of serotonin neurons from human pluripotent stem cells. J Exp Med 34 89 PMID: 26655496

Henry A et al (2020) Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell 183 1986-2002.e26 PMID: 33333022

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.