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Submit ReviewEtoposide
说明： Topoisomerase II inhibitor
化学名： [5R-[5α,5aβ,8aα,9β(R*)]]-9-[(4,6-Ο-Ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6-(5aH)-one
纯度： ≥99% (HPLC)
生物活性 for Etoposide
Etoposide is a DNA topoisomerase II inhibitor (IC50 = 59.2 μM). Anticancer. Also enhances adeno-associated virus (AAV) transduction of HeLa cells.
化合物库 for Etoposide
Etoposide is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Etoposide
| 分子量 | 588.56 |
| 公式 | C29H32O13 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 33419-42-0 |
| PubChem ID | 36462 |
| InChI Key | VJJPUSNTGOMMGY-MRVIYFEKSA-N |
| Smiles | OC(C(OC)=C3)=C(OC)C=[C@@]3[C@@H]2C1=CC6=C(OCO6)C=C1[C@@H](O[C@]4([H])O[C@@](CO[C@@H](C)O7)([H])[C@]7([H])[C@H](O)[C@H]4O)[C@@H]5[C@@H]2[C@](OC5)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Etoposide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 58.86 | 100 |
制备储备液 for Etoposide
以下数据基于产品分子量 588.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.7 mL | 8.5 mL | 16.99 mL |
| 5 mM | 0.34 mL | 1.7 mL | 3.4 mL |
| 10 mM | 0.17 mL | 0.85 mL | 1.7 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
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产品说明书 for Etoposide
参考文献 for Etoposide
参考文献是支持产品生物活性的出版物。
Burden et al (1996) Toposiomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes. J.Biol.Chem. 271 29238 PMID: 8910583
Hande et al (1998) Etoposide: four decades of development of a topoisomerase II inhibitor. Eur.J.Cancer 34 1514 PMID: 9893622
Terada et al (1993) Antitumor agents.3.Synthesis and biological activity of 4β-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents. J.Med.Chem. 36 1689 PMID: 8389875
Nicolson et al (2016) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens. J.Virol. 90 7019 PMID: 27147738
If you know of a relevant reference for Etoposide, please let us know.
按产品操作查看相关产品
关键词: Etoposide, Etoposide supplier, Topoisomerase, II, inhibitors, inhibits, DNA, Isomerases, VP16, chemotherapeutics, viral, transduction, inhibitor, Viral, Transduction, Enhancers, 1226, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Etoposide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
4 篇 Etoposide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Etoposide 的部分引用包括：
Long et al (2019) Novel peptide dermaseptin-PS1 exhibits anticancer activity via induction of intrinsic apoptosis signalling. J Cell Mol Med 23 1300 PMID: 30461197
Li et al (2013) Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis. J Biol Chem 288 17908 PMID: 23661706
Nicolson (2014) Recombinant adeno-associated virus utilizes host cell nuclear import machinery to enter the nucleus. J Virol 88 4132 PMID: 24478436
Maswadeh et al (2015) Etoposide incorporated into camel milk phospholipids liposomes shows increased activity against fibrosarcoma in a mouse model. Eur J Cancer 2015 743051 PMID: 25821817
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Etoposide 的评论
平均评分: 5 (基于 2 条评论。)
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Etoposide for inducing DSBs.
By
Xiaoyu Zhang on 06/23/2023
分析类型： In Vitro
种属： Mouse
细胞系/组织： neuronal cells
Neurons were treated with 1 uM Etoposide to induce DNA double-strand breaks (DSBs), followed by gH2ax staining to detect DSBs.
Etoposide inhibits growth of melanoma cell line at micromolar concentrations.
By
Anonymous on 02/07/2019
分析类型： In Vitro
种属： Human
细胞系/组织： SK-MEL-28
Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
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- Transcriptional Dysregulation
- Mitochondrial Dysfunction
- Nuclear-Cytoplasmic Transport Interference
- Excitotoxicity
- Stem Cells
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.