Evans Blue tetrasodium salt

Name: Evans Blue tetrasodium salt
Brand: Tocris Bioscience
SKU: 0845
Rating: 5 (1 reviews)

Cat. No. 0845 2 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Dye for assessing cell viability and blood brain barrier permeability; also EAAT inhibitor and iGluR antagonist

化学名： 6,6-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)bis[4-amino- 5-hydroxy-1,3-naphthalenedisulphonic acid] tetrasodium salt

纯度： ≥90% (HPLC)

说明书

引用文献 (2)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Evans Blue tetrasodium salt

Evans Blue tetrasodium salt is a potent inhibitor of L-glutamate uptake into synaptic vesicles. Also inhibits AMPA and kainate receptor-mediated currents (IC₅₀ values are 220 and 150 nM respectively). P2X-selective purinoceptor antagonist. Also a non-permeating dye, stains damaged plasma membrane and enters in the cytoplasm and nucleus, used for checking cell viability.

Optical Data for Evans Blue tetrasodium salt

Emission Color	Red
λ_em	680 nm

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技术数据 for Evans Blue tetrasodium salt

分子量	960.82
公式	C₃₄H₂₄N₆Na₄O₁₄S₄
储存	Store at RT
纯度	≥90% (HPLC)
CAS Number	314-13-6
PubChem ID	101102794
InChI Key	ATNOAWAQFYGAOY-UHFFFAOYSA-J
Smiles	[Na+].[Na+].[Na+].[Na+].CC1=CC(=CC=C1\N=N\C1=C(O)C2=C(C=C1)C(=CC(=C2N)S([O-])(=O)=O)S([O-])(=O)=O)C1=CC(C)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S([O-])(=O)=O)S([O-])(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Evans Blue tetrasodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	9.61	10

制备储备液 for Evans Blue tetrasodium salt

以下数据基于产品分子量 960.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	10.41 mL	52.04 mL	104.08 mL
0.5 mM	2.08 mL	10.41 mL	20.82 mL
1 mM	1.04 mL	5.2 mL	10.41 mL
5 mM	0.21 mL	1.04 mL	2.08 mL

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产品说明书 for Evans Blue tetrasodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Evans Blue tetrasodium salt

参考文献是支持产品生物活性的出版物。

Price and Raymond (1996) Evans blue antagonizes both α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and kainate receptors and modulates desensitization. Mol. Pharmacol. 50 1665 PMID: 8967991

Roseth et al (1995) Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transporter. J.Neurochem. 65 96 PMID: 7790899

Wittenburg et al (1996) P₂-purinoceptor antagonists:II blockade of P₂-purinoceptor subtypes and ecto-nucleotidase by compounds related to Evans blue and trypan blue. Naunyn Schmiedebergs Arch.Pharmacol. 354 491 PMID: 8897453

Schurmann et al (1997) Differential modulation of AMPA receptor mediated currents by Evans Blue in postnatal rat hippocampal neurones. Br.J.Pharmacol. 121 237 PMID: 9154333

Merck Index 12 3952

If you know of a relevant reference for Evans Blue tetrasodium salt, please let us know.

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关键词: Evans Blue tetrasodium salt, Evans Blue tetrasodium salt supplier, AMPA/kainate, antagonist, Potent, inhibitors, inhibits, L-glutamate, reuptake, into, synaptic, vesicles, Selective, P2X, purinergic, purinoceptors, Glutamate, AMPA, Receptors, iGluR, Ionotropic, Kainate, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Monoamine, Neurotran, Labels, and, Stains, Fluorescent, Transporter, Probes, 0845, Tocris Bioscience

2 篇 Evans Blue tetrasodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Evans Blue tetrasodium salt 的部分引用包括：

Uderhardt et al (2019) Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 177 541 PMID: 30955887

Gao et al (2018) Research articleHemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors. Virulence 9 1601 PMID: 30277122

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Used for injection.

By Anonymous on 06/06/2020

分析类型： In Vivo

种属： Mouse

细胞系/组织： muscle

Evans blue solution 50 μl/g body weight injection to allow imaging of necrotic tissue in muscle dystrophy mouse model

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Fluorescent Dyes and Probes Research Product Guide

This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:

Fluorescent Dyes, including dyes for flow cytometry
Fluorescent Probes and Stains, including our new MitoBrilliant^TM mitochondria stains
Tissue Clearing Kits and Reagents
Aptamer-based RNA Imaging Reagents
Fluorescent Probes for Imaging Bacteria
TSA Vivid^TM Fluorophore Kits
TSA Reagents for Enhancing IHC, ICC & FISH Signals