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Submit ReviewFelbamate
说明： NMDA antagonist; acts at glycine site
化学名： 2-Phenyl-1,3-propanedioldicarbamate
纯度： ≥99% (HPLC)
生物活性 for Felbamate
Felbamate is an anticonvulsant, acting as an antagonist at the NMDA-associated glycine binding site.
化合物库 for Felbamate
Felbamate is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Felbamate
| 分子量 | 238.24 |
| 公式 | C11H14N2O4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 25451-15-4 |
| PubChem ID | 3331 |
| InChI Key | WKGXYQFOCVYPAC-UHFFFAOYSA-N |
| Smiles | NC(=O)OCC(COC(N)=O)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Felbamate
参考文献 for Felbamate
参考文献是支持产品生物活性的出版物。
Coffin et al (1994) Selective antagonism of the anticonvulsant effects of felb. by glycine. Eur.J.Pharmacol. 256 R9 PMID: 8050461
De Sarro et al (1994) Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felb. in DBA/2 mice. Eur.J.Pharmacol. 262 11 PMID: 7529182
Serra et al (1994) Felbamate antagonises isoniazid- and FG7142-induced reduction of GABAA receptor function in the mouse brain. Eur.J.Pharmacol. 265 185 PMID: 7875235
Upton (1994) Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TiPS 15 456 PMID: 7886818
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关键词: Felbamate, Felbamate supplier, NMDA, antagonist, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 0869, Tocris Bioscience
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Block of NMDA receptor glycine site.
By
Sergiy Sylantyev on 10/15/2020
种属： Human
细胞系/组织： Stem cell - derived neurons
Felbamate was in use as an NMDA receptor antagonist affecting glycine site, to study (possible) competition of dopamine for this site. Application of felbamate and dopamine mixtures in different ratios resulted in a significant decrease of single-channel NMDA receptor openings recorded from outside-out neuron membrane patches. No problem with dissolution in DMSO. Illustration: the effect of 75% dopamine EC50 + 25% Felbamate EC50 on NMDA receptor single-channel openings (top trace); then 50%/50% and 25%/75% ratios.
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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