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Ferrostatin 1

Cat. No. 5180 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective inhibitor of erastin induced ferroptosis
化学名： Ethyl 3-amino-4-(cyclohexylamino)benzoate
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
文献 (3)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ferrostatin 1

Ferrostatin 1 is a selective inhibitor of erastin induced ferroptosis (EC50 = 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.

化合物库 for Ferrostatin 1

Ferrostatin 1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Ferrostatin 1

分子量 262.35
公式 C15H22N2O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 347174-05-4
PubChem ID 4068248
InChI Key UJHBVMHOBZBWMX-UHFFFAOYSA-N
Smiles O=C(OCC)C1=CC(N)=C(NC2CCCCC2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ferrostatin 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 26.23 100
ethanol 26.23 100

制备储备液 for Ferrostatin 1

以下数据基于产品分子量 262.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.81 mL 19.06 mL 38.12 mL
5 mM 0.76 mL 3.81 mL 7.62 mL
10 mM 0.38 mL 1.91 mL 3.81 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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产品说明书 for Ferrostatin 1

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化学品安全技术说明书

参考文献 for Ferrostatin 1

参考文献是支持产品生物活性的出版物。

Dixon et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149 1060 PMID: 22632970

Louandre et al (2013) Iron-dependent cell death of hepatocellular carcinoma cells exposed to sora. Int.J.Cancer 133 1732 PMID: 23505071

Skouta et al (2014) FerroSTAT inhibit oxidative lipid damage and cell death in diverse disease models. J.Am.Chem.Soc. 136 4551 PMID: 24592866

If you know of a relevant reference for Ferrostatin 1, please let us know.

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关键词: Ferrostatin 1, Ferrostatin 1 supplier, Selective, inhibitors, inhibits, erastin, induced, ferroptosis, RAS, selective, lethal, compound, RSL, ROS, Ferroptosis, 5180, Tocris Bioscience

1 篇 Ferrostatin 1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ferrostatin 1 的部分引用包括：

Bi et al (2019) Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis 10 682 PMID: 31527591

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Ferrostatin 1 的评论

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Ferroptosis-related studies.
By MARINA KOUTSIOUMPA on 10/13/2022
分析类型： In Vitro
种属： Human

Combinatorial treatments of Ferrostatin 1 with other chemotherapeutic drugs were performed to elucidate the dependence of the latter on the induction of ferroptosis. Results were consistent.

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