Fexofenadine hydrochloride

Name: Fexofenadine hydrochloride
Brand: Tocris Bioscience
SKU: 2429

Cat. No. 2429 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2429 has been discontinued.

View all Histamine H<sub>1</sub> Receptors products.

说明： H₁ receptor antagonist; non-sedating antiallergic agent

别名： MDL 16455,Terfenidine

化学名： α,α-Dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-benzeneacetic acid hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (1)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Fexofenadine hydrochloride

Fexofenadine hydrochloride is a selective histamine H₁ receptor antagonist (pK_i = 8.1). Active metabolite of Terfenadine (Cat. No. 3948) that displays non-sedating antiallergic effects. Fexofenadine hydrochloride counteracts histamine mediated immune suppression and improves immunotherapy response.

化合物库 for Fexofenadine hydrochloride

Fexofenadine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Fexofenadine hydrochloride

分子量	538.12
公式	C₃₂H₃₉NO₄.HCl
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	153439-40-8
PubChem ID	63002
InChI Key	RRJFVPUCXDGFJB-UHFFFAOYSA-N
Smiles	Cl.CC(C)(C(O)=O)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Fexofenadine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Fexofenadine hydrochloride

参考文献是支持产品生物活性的出版物。

Markham and Wagstaff (1998) Fexofenadine. Drugs 55 269 PMID: 9506246

Sakairi et al (2005) Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. Pharmacology 75 76 PMID: 16037679

Gillard and Chatelaine (2006) Changes in pH differently affect the binding properties of histamine H₁ receptor antagonists. Eur.J.Pharmacol. 530 205 PMID: 16388798

Li et al (2022) The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. Cancer Cell 40 36 PMID: 34822775

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Histamine H₁ Receptor Antagonists

关键词: Fexofenadine hydrochloride, Fexofenadine hydrochloride supplier, H1, receptor, antagonists, non-sedating, antiallergic, agent, Receptors, Histamine, histaminergic, MDL16455, MDL, 16455, Terfenidine, 2429, Tocris Bioscience

1 篇 Fexofenadine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Fexofenadine hydrochloride 的部分引用包括：

Won et al (2013) A modified grapefruit juice eliminates two compound classes as major mediators of the grapefruit juice-fexofenadine interaction: an in vitro-in vivo " connect". Mucosal Immunol 53 982 PMID: 23878024