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Submit ReviewFHT 2344
说明： Potent SMARCA2/4 inhibitor
化学名： N-[(1S)-1-(Methoxymethyl)-2-[[4-[3-(1-methyl-1H-pyrazol-3-yl)phenyl]-2-thiazolyl]amino]-2-oxoethyl]-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide
纯度： ≥95% (HPLC)
生物活性 for FHT 2344
FHT 2344 is a potent allosteric and ATP-competitive inhibitor of SMARCA2/SMARCA4 ATPases (also known as BRM/BRG1) of the BAF complex (IC50 values are 13.8 and 26.1 nM at SMARCA2 and SMARCA4, respectively). FHT 2344 inhibits SMARCA2 transcriptional activity in a BRG1-mutant cell line and SMARCA4 transcription in a BRM-mutant cell line (IC50 values are 29.8 and 30.2 nM, respectively). Dose-dependently reduces tumor growth in a uveal melanoma xenograft model and suppresses SOX10 transcription.
许可信息
Sold under license from Foghorn Therapeutics
技术数据 for FHT 2344
| 分子量 | 528.6 |
| 公式 | C23H24N6O5S2 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2468058-90-2 |
| InChI Key | APLVGTKXOIMODQ-IBGZPJMESA-N |
| Smiles | COC[C@@H](C(NC1=NC(C2=CC(C3=NN(C=C3)C)=CC=C2)=CS1)=O)NC(C4=CN(S(C)(=O)=O)C=C4)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for FHT 2344
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 26.43 | 50 |
制备储备液 for FHT 2344
以下数据基于产品分子量 528.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.78 mL | 18.92 mL | 37.84 mL |
| 2.5 mM | 0.76 mL | 3.78 mL | 7.57 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
| 25 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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产品说明书 for FHT 2344
参考文献 for FHT 2344
参考文献是支持产品生物活性的出版物。
Centore et al (2021) Discovery of novel BAF inhibitors for the treatment of transcription factor-driven cancers. Cancer Res. 81 1224
If you know of a relevant reference for FHT 2344, please let us know.
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关键词: FHT 2344, FHT 2344 supplier, FHT2344, SMARCA, SMARCA2, SMARCA4, potent, inhibitor, inhibitors, BRM, BRG1, BAF, complex, transcription, tumour, tumor, uveal, melanoma, xenograft, SOX10, Bromodomains, Other, ATPases, 7645, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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