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Submit ReviewFK 866 hydrochloride
Discontinued Product
This product has been withdrawn from sale and is superseded by FK 866 (Cat. No. 8072)
说明： Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
化学名： 2-(E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for FK 866 hydrochloride
FK 866 hydrochloride is a non-competitive and potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by etoposide (Cat. No. 1226) and cisplatin (Cat. No. 2251).
技术数据 for FK 866 hydrochloride
| 分子量 | 427.97 |
| 公式 | C24H29N3O2.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2727965-45-7 |
| PubChem ID | 78243733 |
| InChI Key | MULSIBUGDPOSHV-CALJPSDSSA-N |
| Smiles | O=C(C2=CC=CC=C2)N1CCC(CCCCNC(/C=C/C3=CN=CC=C3)=O)CC1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for FK 866 hydrochloride
参考文献 for FK 866 hydrochloride
参考文献是支持产品生物活性的出版物。
Travelli et al (2011) Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etop. or cisp. in neuroblastoma cells. J.Pharmacol.Exp.Ther. 338 829 PMID: 21685314
Hasmann et al (2003) FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res. 63 7436 PMID: 14612543
Galli et al (2008) Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage. ChemMedChem 3 771 PMID: 18247435
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关键词: FK 866 hydrochloride, FK 866 hydrochloride supplier, FK866, hydrochloride, Nicotinamide, phosphoribosyltransferase, NMPRTase, inhibitors, inhibits, autophagy, apoptosis, NAD, NAMPT, visfatin, PBEF, Apoptosis, Inducers, Autophagy, 4808, Tocris Bioscience
2 篇 FK 866 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 FK 866 hydrochloride 的部分引用包括：
Ian A et al (2021) Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation. Cell Metab 33 94-109.e8 PMID: 33159852
Singh et al (2018) Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of MTX through Enhanced Depletion of Intracellular ATP. J Pharmacol Exp Ther 365 96 PMID: 29420256
FK 866 hydrochloride 的评论
平均评分: 5 (Based on 1 Review.)
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NAD inhibitor.
By
Kishor Pant on 04/07/2022
分析类型： In Vitro
种属： Human
细胞系/组织： Cancer and liver cell lines
FK866 Inhibits NAD+ production and NAMPT activity in cancer cells.
Inhibition of NAD in cancer cells requires 3-4 days of treatment
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