Flecainide acetate

Cat. No. 1470 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Cardiac Na⁺ channel blocker. Antiarrhythmic

化学名： N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate

纯度： ≥99% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Flecainide acetate

Flecainide acetate is an open Na⁺ channel blocker that inhibits fast Na⁺ current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.

化合物库 for Flecainide acetate

Flecainide acetate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Flecainide acetate

分子量	474.4
公式	C₁₇H₂₀F₆N₂O₃.C₂H₄O₂
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	54143-56-5
PubChem ID	41022
InChI Key	RKXNZRPQSOPPRN-UHFFFAOYSA-N
Smiles	CC(O)=O.FC(F)(F)COC1=CC=C(OCC(F)(F)F)C(=C1)C(=O)NCC1CCCCN1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Flecainide acetate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	11.86	25
	DMSO	47.44	100

制备储备液 for Flecainide acetate

以下数据基于产品分子量 474.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.11 mL	10.54 mL	21.08 mL
5 mM	0.42 mL	2.11 mL	4.22 mL
10 mM	0.21 mL	1.05 mL	2.11 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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产品说明书 for Flecainide acetate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Flecainide acetate

参考文献是支持产品生物活性的出版物。

Banitt et al (1977) Antiarrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides. J.Med.Chem. 20 821 PMID: 874956

Rouet and Ducouret (1994) Use-and concentration-dependent effects of fleca. in guinea pig right ventricular muscle. J.Cardiovasc.Pharmacol. 24 177 PMID: 7526048

Singh et al (1984) The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions. Ann.N.Y.Acad.Sci. 17 251 PMID: 6395762

If you know of a relevant reference for Flecainide acetate, please let us know.

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关键词: Flecainide acetate, Flecainide acetate supplier, Cardiac, Na+, channel, blockers, Antiarrhythmic, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, 1470, Tocris Bioscience

1 篇 Flecainide acetate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Flecainide acetate 的部分引用包括：

Yu et al (2014) Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. J Neurosci 9 e96691 PMID: 24798465

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