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Floxuridine

Cat. No. 4659 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4659 has been discontinued.

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说明： Thymidylate synthetase inhibitor
别名： FdUrd
化学名： 5-Fluoro-2'-deoxyuridine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (4)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Floxuridine

Floxuridine is an antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.

技术数据 for Floxuridine

分子量 246.19
公式 C9H11FN2O5
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 50-91-9
PubChem ID 5790
InChI Key ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Smiles O[C@H]1C[C@H](N2C=C(F)C(NC2=O)=O)O[C@@H]1CO

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Floxuridine

参考文献是支持产品生物活性的出版物。

Huehls et al (2012) Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells. Cancer Res. 71 4944 PMID: 21613406

Bapat et al (1983) Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. J.Biol.Chem. 258 4130 PMID: 6220000

Wyatt and Wilson (2009) Participation of DNA repair in the response to 5-fluorouracil. Cell.Mol.Life Sci. 66 788 PMID: 18979208

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关键词: Floxuridine, Floxuridine supplier, FdUrd, antiproliferatives, antineoplastic, antimetabolites, thymidylate, synthetases, synthases, inhibititors, DNA, synthesis, chemotherapeutics, DNA,, RNA, and, Protein, Synthesis, Thymidylate, Synthetase, 4659, Tocris Bioscience

1 篇 Floxuridine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Floxuridine 的部分引用包括：

Tiwari et al (2017) Zika virus infection reprograms global transcription of host cells to allow sustained infection. Emerg Microbes Infect 6 e24 PMID: 28442752

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cancer Metabolism Research Product Guide

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

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In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for Floxuridine

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.
p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.