Flunarizine dihydrochloride

Discontinued Product

0522 has been discontinued.

View all Voltage-gated Sodium (Na<sub>V</sub>) Channels products.
说明: Dual Na+/Ca2+ channel (T-type) blocker
化学名: (E)-1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
说明书
引用文献
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生物活性 for Flunarizine dihydrochloride

Dual Na+/Ca2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.

技术数据 for Flunarizine dihydrochloride

分子量 477.42
公式 C26H26F2N2.2HCl
储存 Desiccate at RT
CAS Number 30484-77-6
PubChem ID 5282407
InChI Key RXKMOPXNWTYEHI-RDRKJGRWSA-N
Smiles Cl[H].Cl[H].FC1=CC=C(C=C1)C(N1CCN(C\C=C\C2=CC=CC=C2)CC1)C1=CC=C(F)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Flunarizine dihydrochloride

参考文献 for Flunarizine dihydrochloride

参考文献是支持产品生物活性的出版物。

Eichler et al (1994) The ability of diphenylpiperazines to prevent neuronal death in dorsal root ganglion neurons in vitro after axotomy. J.Neurochem. 62 2148 PMID: 8189223

Pauwels et al (1991) Ca+ and Na+ channels involved in neuronal cell death - protection by flunar. Life.Sci. 48 1881 PMID: 1850815

Urenjak and Obrenovitch (1996) Pharmacological modulation of voltage gated Na+ channels: a rational and effective strategy against ischemic brain damage. Pharmacol.Rev. 48 21 PMID: 8685246

关键词: Flunarizine dihydrochloride, Flunarizine dihydrochloride supplier, Dual, Na+/Ca2+, channel, T-type, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Na+, Calcium, CaV, Ca2+, Voltage-gated, Cav3.x, 0522, Tocris Bioscience

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Pharmacological manipulation of neuronal activity.
By Anonymous on 01/04/2018
分析类型: In Vitro
种属: Mouse
细胞系/组织: primary neurons

To alter neuronal activity in vitro.