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Submit ReviewFlupenthixol dihydrochloride
说明： Dopamine antagonist
别名： Flupentixol
化学名： 4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochloride
纯度： ≥99% (HPLC)
生物活性 for Flupenthixol dihydrochloride
Flupenthixol dihydrochloride is an antipsychotic drug. Exhibits antagonistic activity at dopamine D1-5 receptors. Used in schizophrenia treatment.
This compound is a mixture of E/Z isomers (ratio: 60:40).
化合物库 for Flupenthixol dihydrochloride
Flupenthixol dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Flupenthixol dihydrochloride
| 分子量 | 507.44 |
| 公式 | C23H25F3N2OS.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 2413-38-9 |
| PubChem ID | 17011 |
| InChI Key | IOVDQEIIMOZNNA-UHFFFAOYSA-N |
| Smiles | Cl.Cl.OCCN1CCN(CCC=C2C3=CC(=CC=C3SC3=C2C=CC=C3)C(F)(F)F)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Flupenthixol dihydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 50.74 | 100 | |
| DMSO | 25.37 | 50 |
制备储备液 for Flupenthixol dihydrochloride
以下数据基于产品分子量 507.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.97 mL | 9.85 mL | 19.71 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.94 mL |
| 10 mM | 0.2 mL | 0.99 mL | 1.97 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
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产品说明书 for Flupenthixol dihydrochloride
参考文献 for Flupenthixol dihydrochloride
参考文献是支持产品生物活性的出版物。
Peuch et al (1981) Pharmacological properties of new antipsychotic agents: Use of animal models. Neuropharmacology 20 1279 PMID: 6119637
If you know of a relevant reference for Flupenthixol dihydrochloride, please let us know.
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关键词: Flupenthixol dihydrochloride, Flupenthixol dihydrochloride supplier, Flupenthixol, 2HCl, dopamine, receptor, antagonist, antipsychotic, drug, schizophrenia, Flupentixol, Non-selective, Dopamine, 4057, Tocris Bioscience
6 篇 Flupenthixol dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Flupenthixol dihydrochloride 的部分引用包括：
Nicole F et al (2013) Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity. Biol Psychiatry 73 464-71 PMID: 23140663
Regna et al (2016) A critical role for the Drosophila DA D1-like receptor Dop1R2 at the onset of metamorphosis. PLoS One 16 15 PMID: 27184815
Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643
Eero et al (2022) Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro. Front Pharmacol 12 755600 PMID: 35126106
FitzGerald et al (2014) A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. PLoS One 9 e98891 PMID: 24902048
Clive R et al (2021) Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell 184 1299-1313.e19 PMID: 33606976
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.