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Submit ReviewFluticasone propionate
说明： Selective high affinity glucocorticoid receptor agonist
化学名： (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester
纯度： ≥98% (HPLC)
生物活性 for Fluticasone propionate
Fluticasone propionate is a high affinity, selective glucocorticoid receptor agonist (Kd = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates KV1 channels (EC50 = 37 nM).
许可信息
Sold for research purposes under agreement from GlaxoSmithKline
化合物库 for Fluticasone propionate
Fluticasone propionate is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Fluticasone propionate
| 分子量 | 500.57 |
| 公式 | C25H31F3O5S |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 80474-14-2 |
| PubChem ID | 444036 |
| InChI Key | WMWTYOKRWGGJOA-CENSZEJFSA-N |
| Smiles | O=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@@](F)2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H](C)[C@](C(SCF)=O)4OC(CC)=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Fluticasone propionate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 25.03 | 50 |
制备储备液 for Fluticasone propionate
以下数据基于产品分子量 500.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4 mL | 19.98 mL | 39.95 mL |
| 2.5 mM | 0.8 mL | 4 mL | 7.99 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
| 25 mM | 0.08 mL | 0.4 mL | 0.8 mL |
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产品说明书 for Fluticasone propionate
参考文献 for Fluticasone propionate
参考文献是支持产品生物活性的出版物。
Johnson (1995) The anti-inflammatory profile of flutic. propionate. Allergy 50 11 PMID: 7604948
Zhang et al (2000) Enhancement of human eosinophil apoptosis by flutic. propionate, budesonide, and beclometh. Eur.J.Pharmacol. 406 325 PMID: 11040338
Smith and Kreutner (1998) In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids. Arzneim.-Forsch. 48 956
Pan et al (2012) Potentiation of the Kv1 family K+ channel by cortisone analogues. ACS Chem.Biol. 7 1641 PMID: 22803826
If you know of a relevant reference for Fluticasone propionate, please let us know.
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关键词: Fluticasone propionate, Fluticasone propionate supplier, Selective, high, affinity, glucocorticoid, agonists, Receptors, GlaxoSmithKline, GSK, Glucocorticoid, Receptor, Voltage-Gated, Potassium, Channels, 2007, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Fluticasone propionate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.